ArticleNature communications2019
Mitochondrial oxidative capacity and NAD
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In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 1 pooled it
13.8field-weighted citation impact, top 1% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
210 citing papers in PubMed, 1 synthesis or guideline pooled it, 330 citations in OpenAlex.
- Pulse Wave Velocity and Sarcopenia in Older Persons-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Efficacy of leucine-rich high protein supplementation on body composition and muscle function among older adults with sarcopenia: a randomized controlled trial.European journal of nutrition · 2026Trial
- Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in men.Nature communications · 2025Trial
- Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.Cell reports. Medicine · 2022Trial
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial.The journal of nutrition, health & aging · 2022Trial
- Trial
- Micronutrients and omega-3 PUFAs to promote healthy ageing: informing a physiology-based complementation strategy.GeroScience · 2026Review
- Inotodiol prevents age-related muscle wasting by restoring mitochondrial function through liver X receptor beta signaling.Signal transduction and targeted therapy · 2026Article
- Article
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- Impaired liver-muscle lactate metabolism causes sarcopenia via lactic acidosis in skeletal muscle in mice.Science advances · 2026Article
- The hallmarks of skeletal muscle health.Nature metabolism · 2026Review
- Machine Learning-Derived Sarcopenia Signature Identifies High-Risk Molecular State in T2D Skeletal Muscle.Cell biochemistry and biophysics · 2026Article
- Integrated transcriptomic and in silico structural analysis identifies NFS1 and HSPA9 as potential regulators associated with mitochondrial ferroptosis and cell death resistance in colorectal cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Transcriptomic profiling and structural characterization reveal UQCRC1 and COX4I1 as key mitochondrial regulators associated with oxidative stress in multiple sclerosis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Targeting TWEAK to enhance mitochondrial biogenesis and attenuate age-related muscle mass loss.Scientific reports · 2026Article
- Ferroptosis-related stress during aging and its relevance to disease.GeroScience · 2026Review
- Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial.GeroScience · 2026Article
- Identification of Potential Biomarkers Associated with Impaired Fatty Acid Oxidation in Aged Skeletal Muscle Using Bioinformatics and Machine Learning Approaches.Biomolecules · 2026Article
- Protein arginine methyltransferases coordinate mitochondrial stress adaptation and neuromuscular function.Experimental & molecular medicine · 2026Review
150 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 10 institutions in 6 countries.
Eugenia MigliavaccaNestle Research, EPFL Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-1883-1972
Stacey K H TayKTP-National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Harnish P PatelMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0002-0081-1802
Tanja SonntagNestle Research, EPFL Innovation Park, Lausanne, Switzerland.
Gabriele CivilettoNestle Research, EPFL Innovation Park, Lausanne, Switzerland.
Craig McFarlaneDepartment of Molecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
Terence ForresterUWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica.
Sheila J BartonMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Melvin K LeowSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.ORCID http://orcid.org/0000-0002-2837-5889
Elie AntounInstitute of Developmental Sciences, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0002-9477-1564
Aline CharpagneNestle Research, EPFL Innovation Park, Lausanne, Switzerland.
Yap Seng ChongSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.ORCID http://orcid.org/0000-0002-7232-8473
Patrick DescombesNestle Research, EPFL Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1274-247X
Lei FengDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Patrice Francis-EmmanuelUWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica.
Emma S GarrattNational Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Maria Pilar GinerNestle Research, EPFL Innovation Park, Lausanne, Switzerland.
Curtis O GreenUWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica.
Sonia KarazNestle Research, EPFL Innovation Park, Lausanne, Switzerland.
Narasimhan KothandaramanSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.
Julien MarquisNestle Research, EPFL Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2020-1534
Sylviane MetaironNestle Research, EPFL Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-2434-8733
Sofia MocoNestle Research, EPFL Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8170-8876
Gail NelsonUWI Solutions for Developing Countries, UWI SODECO, University of West Indies, Kingston, Jamaica.
Sherry NgoLiggins Institute, University of Auckland, Auckland, New Zealand.
Tony PleasantsLiggins Institute, University of Auckland, Auckland, New Zealand.
Frederic RaymondNestle Research, EPFL Innovation Park, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6148-6898
Avan A SayerAcademic Geriatric Medicine, , University of Southampton, Southampton, UK.
Chu Ming SimSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.
Jo Slater-JefferiesInstitute of Developmental Sciences, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0001-8325-1320
Holly E SyddallMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Pei Fang TanSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.
Philip TitcombeMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Candida VazSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.
Leo D WestburyMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Gerard WongSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.
Wu YonghuiSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.
Cyrus CooperMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0003-3510-0709
Allan SheppardLiggins Institute, University of Auckland, Auckland, New Zealand.
Keith M GodfreyMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. kmg@mrc.soton.ac.uk.ORCID http://orcid.org/0000-0002-4643-0618
Karen A LillycropNational Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. K.A.Lillycrop@soton.ac.uk.
Neerja KarnaniSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore. neerja_karnani@sics.a-star.edu.sg.
Jerome N FeigeNestle Research, EPFL Innovation Park, Lausanne, Switzerland. Jerome.feige@rd.nestle.com.ORCID http://orcid.org/0000-0002-4751-264X
Nestlé (Switzerland) · CHAgency for Science, Technology and Research · SGUniversity Hospital Southampton NHS Foundation Trust · GBMRC Lifecourse Epidemiology Unit · GBUniversity of the West Indies · JMUniversity of Auckland · NZNational University of Singapore · SGUniversity of Southampton · GBJames Cook University · AUNIHR Newcastle Biomedical Research Centre · GB
Funding
Interdisciplinary Research Network on Early Adversity & Later Life ReversibilityU24AG047867 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GODFREY, KEITH, MCEWEN, BRUCE S. · 2014 to 2018
$954kMedical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council MC_UU_12011/4NIA NIH HHS U24 AG047867
Abstract
The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopenia versus age-matched controls in muscle biopsies from 119 older men from Singapore, Hertfordshire UK and Jamaica. Individuals with sarcopenia reproducibly demonstrate a prominent transcriptional signature of mitochondrial bioenergetic dysfunction in skeletal muscle, with low PGC-1α/ERRα signalling, and downregulation of oxidative phosphorylation and mitochondrial proteostasis genes. These changes translate functionally into fewer mitochondria, reduced mitochondrial respiratory complex expression and activity, and low NAD
Indexed as
AgedAged, 80 and overAgingBiopsyCase-Control StudiesEnergy MetabolismHumansJamaicaMaleMiddle AgedMitochondriaMuscle, SkeletalNADOxidation-ReductionOxidative PhosphorylationOxidative StressNAD
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.