ArticleGenetics2020
Evolution of Specialization in Heterogeneous Environments: Equilibrium Between Selection, Mutation and Migration.
Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Phenotype structuring in collective cell migration: a tutorial of mathematical models and methods.Journal of mathematical biology · 2025Review
- Evolution and spread of multiadapted pathogens in a spatially heterogeneous environment.Evolution letters · 2024Article
- Eco-evolutionary model on spatial graphs reveals how habitat structure affects phenotypic differentiation.Communications biology · 2022Article
- Evolutionary dynamics of complex traits in sexual populations in a heterogeneous environment: how normal?Journal of mathematical biology · 2022Article
- Adaptation to DNA Damage, an Asymptotic Approach for a Cooperative Non-local System.Acta applicandae mathematicae · 2022Article
- Adaptation in a heterogeneous environment I: persistence versus extinction.Journal of mathematical biology · 2021Article
- A Mathematical Study of the Influence of Hypoxia and Acidity on the Evolutionary Dynamics of Cancer.Bulletin of mathematical biology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Adaptation in spatially heterogeneous environments results from the balance between local selection, mutation, and migration. We study the interplay among these different evolutionary forces and demography in a classical two-habitat scenario with asexual reproduction. We develop a new theoretical approach that goes beyond the Adaptive Dynamics framework, and allows us to explore the effect of high mutation rates on the stationary phenotypic distribution. We show that this approach improves the classical Gaussian approximation, and captures accurately the shape of this equilibrium phenotypic distribution in one- and two-population scenarios. We examine the evolutionary equilibrium under general conditions where demography and selection may be nonsymmetric between the two habitats. In particular, we show how migration may increase differentiation in a source-sink scenario. We discuss the implications of these analytic results for the adaptation of organisms with large mutation rates, such as RNA viruses.
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Registered trials
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