ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
The Nucleus Accumbens Core Is Necessary for Responding to Incentive But Not Instructive Stimuli.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Cortico-Striatal-Midbrain Circuit Dysregulation Underlying MK-801 Induced Impulsivity and the Ameliorative Effects of SEP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Adult Striatal Neurogenesis-A Comparative Approach Between Pigeons, Mice, Macaques, and Human.The Journal of comparative neurology · 2025Article
- Reward expectation and receipt differentially modulate the spiking of accumbens D1+ and D2+ neurons.Current biology : CB · 2025Article
- Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system.Current biology : CB · 2025Article
- Environmental enrichment enhances ethanol preference over social reward in male swiss mice: Involvement of oxytocin-dopamine interactions.Neuropharmacology · 2024Article
- Distinct Action Signals by Subregions in the Nucleus Accumbens during STOP-Change Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cortical-striatal brain network distinguishes deepfake from real speaker identity.Communications biology · 2024Article
- Two Distinct Neuronal Populations in the Rat Parafascicular Nucleus Oppositely Encode the Engagement in Stimulus-driven Reward-seeking.Current neuropharmacology · 2024Article
- Contexts facilitate dynamic value encoding in the mesolimbic dopamine system.bioRxiv : the preprint server for biology · 2023Article
- Quantifying the instrumental and noninstrumental underpinnings of Pavlovian responding with the Price equation.Psychonomic bulletin & review · 2022Review
- Threat and Bidirectional Valence Signaling in the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Monosynaptic Retrograde Tracing From Prelimbic Neuron Subpopulations Projecting to Either Nucleus Accumbens Core or Rostromedial Tegmental Nucleus.Frontiers in neural circuits · 2021Article
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4 authors.
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Abstract
An abundant literature has highlighted the importance of the nucleus accumbens core (NAcC) in behavioral tasks dependent on external stimuli. Yet, some studies have also reported the absence of involvement of the NAcC in stimuli processing. We aimed at comparing, in male rats, the underlying neuronal determinants of incentive and instructive stimuli in the same task. We developed a variant of a GO/NOGO task that reveals important differences in these two types of stimuli. The incentive stimulus invites the rat to engage in the task sequence. Once the rat has decided to initiate a trial, it remains engaged in the task until the end of the trial. This task revealed the differential contribution of the NAcC to responding to different types of stimuli: responding to the incentive stimulus depended on NAcC AMPA/NMDA and dopamine D1 receptors, but the retrieval of the response associated with the instructive stimuli (lever pressing on GO, withholding on NOGO) did not. Our electrophysiological study showed that more NAcC neurons responded more strongly to the incentive than the instructive stimuli. Furthermore, when animals did not respond to the incentive stimulus, the induced excitation was suppressed for most projection neurons, whereas interneurons were strongly activated at a latency preceding that found in projection neurons. This work provides insight on the underlying neuronal processes explaining the preferential implication of the NAcC in deciding whether and when to engage in reward-seeking rather than to decide which action to perform.
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