Evidence map›Paper›PMID 31862843›Full record

ArticleDevelopment (Cambridge, England)2020

Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation.

Jesse R Raab, Deepthi Y Tulasi, Kortney E Wager, Jeremy M Morowitz, Scott T Magness, Adam D Gracz

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Tet1 safeguards lineage allocation in intestinal stem cells.bioRxiv : the preprint server for biology · 2025
    Article
  4. Intestinal stem cell niche: An upcoming area of immense importance in gastrointestinal disorders.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Epigenetic regulation of intestinal stem cell differentiation.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jesse R RaabDepartment of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA.ORCID 0000-0001-6387-8994
Deepthi Y TulasiDepartment of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA.
Kortney E WagerDepartment of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA.
Jeremy M MorowitzDepartment of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA.
Scott T MagnessCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, NC 27599, USA.
Adam D GraczDepartment of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA agracz@med.unc.edu.ORCID 0000-0003-1298-568X
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
Genetic Control of Intestinal Epithelial Stem Cell Maintenance & DifferentiationR01DK091427 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAGNESS, SCOTT T · 2011 to 2015
$1.6M
Mechanisms and function of Tet1 regulated gene networks in intestinal stem cell biologyK01DK111709 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRACZ, ADAM DAVID · 2016 to 2019
$389k
Determining the role of Tet1 in intestinal stem cell differentiation and self-renewalR03DK122111 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRACZ, ADAM DAVID · 2019 to 2020
$234k
NCI NIH HHS P30 CA016086NIDDK NIH HHS K01 DK111709NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK091427NIDDK NIH HHS R03 DK122111
6 · The paper itself

Abstract

Intestinal stem cell (ISC) plasticity is thought to be regulated by broadly permissive chromatin shared between ISCs and their progeny. Here, we have used a Sox9

Indexed as

Cell DifferentiationAnimalsChromatinChromatin Assembly and DisassemblyDNA MethylationGene Expression ProfilingGene Regulatory NetworksGenes, ReporterIntestinesMaleMiceMice, Inbred C57BLOrgan Culture TechniquesSOX9 Transcription FactorStem CellsChromatinSox9 protein, mouseSOX9 Transcription Factor5hmCChromatinDifferentiationId3Intestinal stem cell

Identifiers

PMID31862843
PMCPMC6983707
OpenAlexW2994932230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.