Evidence map›Paper›PMID 31862842›Full record

ArticleDevelopment (Cambridge, England)2020

Deficient autophagy in epithelial stem cells drives aging in the freshwater cnidarian

Szymon Tomczyk, Nenad Suknovic, Quentin Schenkelaars, Yvan Wenger, Kazadi Ekundayo, Wanda Buzgariu, Christoph Bauer, Kathleen Fischer, Steven Austad, Brigitte Galliot

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Autophagy · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Genome research · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A novel regulatory gene promotes novel cell fate by suppressing ancestral fate in the sea anemoneProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Nontraditional systems in aging research: an update.Cellular and molecular life sciences : CMLS · 2021
    Review
  20. The Evolution of the Hallmarks of Aging.Frontiers in genetics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Szymon TomczykDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland.ORCID 0000-0002-2283-3156
Nenad SuknovicDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland.
Quentin SchenkelaarsDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland.ORCID 0000-0002-8622-6443
Yvan WengerDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland.ORCID 0000-0002-6162-1527
Kazadi EkundayoDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland.
Wanda BuzgariuDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland.ORCID 0000-0002-8492-6470
Christoph BauerDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland.ORCID 0000-0002-0783-8119
Kathleen FischerDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-4431-4629
Steven AustadDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-4798-8442
Brigitte GalliotDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, CH-1205 Geneva, Switzerland brigitte.galliot@unige.ch.ORCID 0000-0001-7596-8284
University of Geneva · CHUniversity of Alabama at Birmingham · US

Funding

Hydra: New Models for Aging ResearchR01AG037962 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AUSTAD, STEVEN N. · 2010 to 2014
$1.2M
NIA NIH HHS R01 AG037962
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AutophagyFresh WaterAgingAnimalsCell ProliferationCold TemperatureEpidermisEpithelial CellsGametogenesisGene Expression Regulation, DevelopmentalHydraImaging, Three-DimensionalPhenotypeProteasome InhibitorsSirolimusStem CellsProteasome InhibitorsSirolimusAging model systemAutophagy sensorEpithelial stem cellsEvolution of agingHydra regenerationp62/SQSTM1RapamycinWIPI2

Identifiers

PMID31862842
PMCPMC6983715
OpenAlexW2995692805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.