ArticleThe European respiratory journal2020
Increased risk of active tuberculosis during pregnancy and postpartum: a register-based cohort study in Sweden.
Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06352970 (Effects of Tuberculosis Infection on Placental Development and Function), which is not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Tuberculosis Infection on Placental Development and Function
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Global estimates of tuberculosis incidence during pregnancy and postpartum: a rapid review and modelling analysis.The Lancet. Global health · 2026Pooled it
- Mycobacterium tuberculosis-Specific T-Cell Responses Are Impaired During Late Pregnancy With Elevated Biomarkers of Tuberculosis Risk Postpartum.The Journal of infectious diseases · 2022Trial
- Infectious comorbidities in pregnant patients with rheumatic diseases.Rheumatology international · 2026Review
- Tuberculosis in Pregnancy: Challenges of Immune Protection.The Journal of infectious diseases · 2026Review
- Article
- Safety evaluation of pretomanid, an anti-tuberculosis drug, for the treatment of pregnant and lactating women.Antimicrobial agents and chemotherapy · 2026Article
- Dual paradoxical reactions in tuberculous lymphadenitis during and after pregnancy: A case report.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2026Article
- Pregnancy among people with TB disease.IJTLD open · 2026Article
- Navigating Tuberculosis in Pregnancy and Lactation: A Review of Maternal and Neonatal Considerations.Diseases (Basel, Switzerland) · 2026Review
- Successful treatment of pre-extensively drug-resistant tuberculous meningoencephalomyelitis in pregnancy with a bedaquiline and delamanid-based regimen: a case report.BMC infectious diseases · 2026Article
- Global Burden of Tuberculosis and Drug-Resistant Subtypes Among Women of Childbearing Age from 1990 to 2021, with Projections to 2030.International journal of women's health · 2026Article
- Tuberculosis Prevention in Pregnant Women Living with HIV: A Review of the Current Management Strategies and Guidance.Infection and drug resistance · 2026Review
- Tuberculosis Preventive Treatment for Pregnant People With HIV in South Africa: A Modeling Analysis of Clinical Benefits and Risks.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Tuberculosis in Pregnant Women After COVID-19: Features of Prevention, Diagnosis, and Treatment (Narrative Review).Journal of clinical medicine · 2025Review
- Clinical Features and Outcomes of Tuberculosis after in Vitro Fertilization-Embryo Transfer Compared with Natural Pregnancy: A Retrospective Study.The American journal of tropical medicine and hygiene · 2025Article
- Article
- The effect of pregnancy on the population pharmacokinetics of levofloxacin in South Africans with rifampicin-resistant tuberculosis.Antimicrobial agents and chemotherapy · 2025Article
- Cascade of care for the diagnosis and treatment of latent tuberculosis infection in an inner-city hospital prenatal clinic.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
- Factors driving adolescent tuberculosis incidence by age and sex in 30 high-tuberculosis burden countries: a mathematical modelling study.BMJ global health · 2025Article
- Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleStudies investigating the risk of active tuberculosis (TB) in association with pregnancy have not been conclusive. We aimed to investigate this risk in a large retrospective register-based cohort study in Sweden.
methodsData from women of 15-49 years of age who had given birth in Sweden between 2005 and 2013 were extracted from the national childbirth register and linked to the national TB register. Cohort time was divided into three exposure periods: during pregnancy, six months (180 days) postpartum and time neither pregnant nor postpartum. We calculated incidence rates (IRs) per 100 000 person-years for each period and incidence rate ratios (IRRs) with IRs neither pregnant nor postpartum as the reference.
resultsThe cohort included 649 342 women, of whom 553 were registered as cases of active TB, 389 when neither pregnant nor postpartum, 85 during pregnancy and 79 when postpartum. Overall IRs were 9, 12 and 17 cases per 100 000 person-years, respectively, giving IRR 1.4, 95% CI 1.1-1.7 (during pregnancy) and IRR 1.9, 95% CI 1.5-2.5 (when postpartum). Stratification by TB incidence in country of origin showed that the increased risk was concentrated amongst women from countries with a TB incidence of 100 or higher, where IRs per 100 000 person-years were 137 (when neither pregnant nor postpartum), 182 (during pregnancy) and 233 (when postpartum).
conclusionWe show a significant increase in risk of active TB during both pregnancy and postpartum in women from high incidence countries and recommend TB screening in pregnant women belonging to this risk group.
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