ArticleJournal of immunology (Baltimore, Md. : 1950)2020
IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early
Open access · bronzeAbstract read
In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- The immunoregulatory landscape of human tuberculosis granulomas.Nature immunology · 2022Pooled it
- A Comparison of Mechanisms Driving Lesion Outcomes During Lung Tumor and Tuberculosis Granuloma Formation.Bulletin of mathematical biology · 2026Article
- Article
- The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas.Nature immunology · 2026Article
- Analysis of immune cytokines and cell surface markers in FFPE biopsy samples from patients with suspected endometrial and lymph Node Tuberculosis.BMC immunology · 2026Article
- Post-TB lung disease: pathogenesis, host-directed therapies, and the C3HeB/FeJ model for pre-clinical advances.Infection and immunity · 2026Review
- CD8+ lymphocytes in immunity against tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Differences in local immune response of bait Mycobacterium bovis heat-inactivated vaccinated badgers showing exacerbated tuberculous lesions after challenge.Scientific reports · 2025Article
- Interleukin-10 family cytokines: key regulators and novel therapeutic targets for respiratory diseases.Inflammopharmacology · 2025Review
- Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden.Journal of theoretical biology · 2025Article
- The Role of Type I Interferons in Tuberculosis and in Tuberculosis-Risk-Associated Comorbidities.Infectious disease reports · 2025Review
- Clinical characteristics and prognostic factors of pulmonary tuberculosis with interstitial changes.BMC infectious diseases · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.Nature communications · 2025Article
- Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.bioRxiv : the preprint server for biology · 2025Article
- Leveraging insights from cancer to improve tuberculosis therapy.Trends in molecular medicine · 2025Article
- Sustained neutrophil infiltration and bacterial grain morphology underlie chronic mycetoma pathology in a murine model.Iranian journal of basic medical sciences · 2025Article
- Recent status and trends regarding oxidative stress in gliomas (2013 - 2025): a systematic review and bibliometric analysis.Frontiers in oncology · 2025Review
- Early introduction of IL-10 weakens BCG revaccination's protection by suppressing CD4Journal of translational medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 1 country.
Eileen A WongDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Stephanie EvansDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Carolyn R KrausNonhuman Primate Reagent Resource, MassBiologics, University of Massachusetts Medical School, Boston, MA 02126.ORCID 0000-0001-7552-099X
Kathleen D EngelmanNonhuman Primate Reagent Resource, MassBiologics, University of Massachusetts Medical School, Boston, MA 02126.ORCID 0000-0002-1233-7335
Pauline MaielloDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.ORCID 0000-0002-5188-8420
Walter J FloresNonhuman Primate Reagent Resource, MassBiologics, University of Massachusetts Medical School, Boston, MA 02126.ORCID 0000-0003-0889-2958
Anthony M CadenaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.ORCID 0000-0002-6788-2090
Edwin KleinDivision of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, PA 15261.
Kayla ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.ORCID 0000-0003-0533-1557
Alexander G WhiteDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Chelsea CausgroveDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Brianne SteinDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Jaime TomkoDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.
Joshua T MattilaDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261; and.ORCID 0000-0002-6384-1291
Hannah GideonDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.ORCID 0000-0002-4443-2134
P Ling LinDepartment of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224.
Keith A ReimannNonhuman Primate Reagent Resource, MassBiologics, University of Massachusetts Medical School, Boston, MA 02126.ORCID 0000-0003-3074-6500
Denise E KirschnerDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-1053-2591
JoAnne L FlynnDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219; joanne@pitt.edu.ORCID 0000-0001-7874-8981
University of Pittsburgh · USUniversity of Massachusetts Chan Medical School · USUniversity of Michigan · USChildren's Hospital of Pittsburgh · US
Funding
Predicting immune responses that correlate with protection against tuberculosisR01HL110811 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2012 to 2016
$5.9MImmunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3MPredicting protective T-cell responses in Tuberculosis using a systems biology approachR01AI123093 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2016 to 2020
$3.6MNHLBI NIH HHS R01 HL110811NIAID NIH HHS R01 AI123093NIAID NIH HHS T32 AI060525
Abstract
Tuberculosis (TB), caused by
Indexed as
AnimalsAntibodies, NeutralizingCells, CulturedDisease Models, AnimalGranulomaHumansImmunityInflammationInterleukin-10LungLymph NodesMacaca fascicularisMycobacterium tuberculosisPulmonary FibrosisTuberculosisAntibodies, NeutralizingInterleukin-10
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.