ArticleChest2020
Ultrashort Echo-Time MRI for the Assessment of Tracheomalacia in Neonates.
Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2021Guideline
- Assessing the feasibility of neonatal chest MRI for bronchopulmonary dysplasia using a standard 1.5-Tesla scanner.European radiology · 2026Article
- Characterizing chronic obstructive pulmonary disease using quantitative MRI biomarkers.The British journal of radiology · 2026Review
- Reducing scan time burden for neonatal MRI of pulmonary structure using FLORET UTE.Magma (New York, N.Y.) · 2026Article
- Impact of Surgical Diaphragmatic Repair on Central Airway Shape in Neonatal Congenital Diaphragmatic Hernia.Pediatric pulmonology · 2026Article
- Back to the future in asthma imaging: quantitative assessment and new perspectives.La Radiologia medica · 2026Review
- Diagnosis, Treatment, and Follow-Up of Tracheo/Bronchomalacia in Children: The Italian Multicenter Experience.Children (Basel, Switzerland) · 2025Article
- Using Positive End-Expiratory Pressure to Predict and Quantify Tracheobronchomalacia in Grade 3 Bronchopulmonary Dysplasia.Pediatric pulmonology · 2025Article
- Vascular and Non-Vascular Intervention in the Pediatric Chest: An Update.Cardiovascular and interventional radiology · 2025Review
- Dynamic Airway CT for Morphometric Analysis of Pediatric Tracheomalacia Throughout Respiration.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Clinical Outcomes Through Two Years for Infants With Bronchopulmonary Dysplasia and Tracheomalacia.Pediatric pulmonology · 2025Observational
- Magnetic resonance imaging was a viable and non-intrusive method for diagnosing tracheomalacia in children.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Correlation of Tracheomalacia Severity With Esophageal Gap Length as Assessed by Ultrashort Echo-time MRI.Journal of pediatric surgery · 2024Article
- Modeling Realistic Geometries in Human Intrathoracic Airways.Diagnostics (Basel, Switzerland) · 2024Review
- Tracheomalacia Reduces Aerosolized Drug Delivery to the Lung.Journal of aerosol medicine and pulmonary drug delivery · 2024Article
- Dynamic computed tomography for evaluation of tracheobronchomalacia in premature infants with bronchopulmonary dysplasia.Pediatric pulmonology · 2023Article
- MR imaging of the airways.The British journal of radiology · 2023Review
- Heliox simulations for initial management of congenital laryngotracheal stenosis.Pediatric pulmonology · 2023Article
- Seeing Premature Lung Disease: Hyperpolarized Xe Magnetic Resonance Imaging.American journal of respiratory and critical care medicine · 2023Article
- Characteristics analysis of 157 cases of central airway stenosis due to tracheobronchial tuberculosis: A descriptive study.Frontiers in public health · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBronchoscopy is the gold standard for evaluating tracheomalacia; however, reliance on an invasive procedure limits understanding of normal airway dynamics. Self-gated ultrashort echo-time MRI (UTE MRI) can assess tracheal dynamics but has not been rigorously evaluated.
methodsThis study was a validation of UTE MRI diagnosis of tracheomalacia in neonates using bronchoscopy as the gold standard. Bronchoscopies were reviewed for the severity and location of tracheomalacia based on standardized criteria. The percent change in cross-sectional area (CSA) of the trachea between end-inspiration and end-expiration was determined by UTE MRI, and receiver-operating curves were used to determine the optimal cutoff values to predict tracheomalacia and determine positive and negative predictive values.
resultsAirway segments with tracheomalacia based on bronchoscopy had a more than threefold change in CSA measured from UTE MRI (54.4 ± 56.1% vs 14.8 ± 19.5%; P < .0001). UTE MRI correlated moderately with bronchoscopy for tracheomalacia severity (ρ = 0.39; P = .0001). Receiver-operating curves, however, showed very good ability of UTE MRI to identify tracheomalacia (area under the curve, 0.78). A "loose" definition (> 20% change in CSA) of tracheomalacia had good sensitivity (80%) but low specificity (64%) for identifying tracheomalacia based on UTE MRI, whereas a "strict" definition (> 40% change in CSA) was poorly sensitive (48%) but highly specific (93%).
conclusionsSelf-gated UTE MRI can noninvasively assess tracheomalacia in neonates without sedation, ionizing radiation, or increased risk. This technique overcomes major limitations of other diagnostic modalities and may be suitable for longitudinal population studies of tracheal dynamics.
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