Evidence map›Paper›PMID 31862403›Full record

ArticleJournal of the American Academy of Dermatology2020

Pathologists' agreement on treatment suggestions for melanocytic skin lesions.

Mustufa A Jafry, Sue Peacock, Andrea C Radick, Hannah L Shucard, Lisa M Reisch, Michael W Piepkorn, Stevan R Knezevich, Martin A Weinstock, Raymond L Barnhill, David E Elder and 2 more

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In one paragraph

Article in Journal of the American Academy of Dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. The potential of x-ray virtual histology in the diagnosis of skin tumors.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mustufa A JafryDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington.
Sue PeacockDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington.
Andrea C RadickDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington.
Hannah L ShucardDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington.
Lisa M ReischDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington.
Michael W PiepkornDivision of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington; Dermatopathology Northwest, Bellevue, Washington.
Stevan R KnezevichPathology Associates, Clovis, California.
Martin A WeinstockCenter for Dermatoepidemiology, Providence VA Medical Center, Providence, Rhode Island; Departments of Dermatology and Epidemiology, Brown University, Providence, Rhode Island.
Raymond L BarnhillDepartment of Pathology, Institut Curie, Paris Sciences and Lettres Research University; Faculty of Medicine, University of Paris Descartes, Paris, France.
David E ElderDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, Washington.
Joann G ElmoreDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington; Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California. Electronic address: jelmore@mednet.ucla.edu.

Funding

Accuracy in the Diagnosis of Melanoma & the Impact of Double ReadingR01CA151306 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G · 2011 to 2015
$4.1M
Reducing Errors in the Diagnosis of Melanoma and Melanocytic LesionsR01CA201376 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, KERR, KATHLEEN F. · 2016 to 2020
$3.2M
Improving Melanoma Pathology Accuracy through Computer Vision Techniques - the IMPACT StudyR01CA200690 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, SHAPIRO, LINDA · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA151306NCI NIH HHS R01 CA200690NCI NIH HHS R01 CA201376
6 · The paper itself

Abstract

backgroundAlthough treatment guidelines exist for melanoma in situ and invasive melanoma, guidelines for other melanocytic skin lesions do not exist.

objectiveTo examine pathologists' treatment suggestions for a broad spectrum of melanocytic skin lesions and compare them with existing guidelines.

methodsPathologists (N = 187) completed a survey and then provided diagnoses and treatment suggestions for 240 melanocytic skin lesions. Physician characteristics associated with treatment suggestions were evaluated with multivariable modeling.

resultsTreatment suggestions were concordant with National Comprehensive Cancer Network guidelines for the majority of cases interpreted as melanoma in situ (73%) and invasive melanoma (86%). Greater variability of treatment suggestions was seen for other lesion types without existing treatment guidelines. Characteristics associated with provision of treatment suggestions discordant with National Comprehensive Cancer Network guidelines were low caseloads (invasive melanoma), lack of fellowship training or board certification (melanoma in situ), and more than 10 years of experience (invasive melanoma and melanoma in situ). LIMITATIONS: Pathologists could not perform immunohistochemical staining or other diagnostic tests; only 1 glass side was provided per biopsy case.

conclusionsPathologists' treatment suggestions vary significantly for melanocytic lesions, with lower variability for lesion types with national guidelines. Results suggest the need for standardization of treatment guidelines for all melanocytic lesion types.

Indexed as

Attitude of Health PersonnelPathology, ClinicalHumansMelanomaNeoplasm InvasivenessSkin Neoplasmsinvasive melanomamelanocytic skin lesionsmelanoma in situpathologyskin biopsiestreatment guidelines

Identifiers

PMID31862403
PMCPMC8824529

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.