ArticleMaterials (Basel, Switzerland)2019
Evaluation of a Zn-2Ag-1.8Au-0.2V Alloy for Absorbable Biocompatible Materials.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Cytocompatibility Assessment of L-PBF-Manufactured Zinc-Silver-Copper Alloys for Customized Biodegradable Medical Implants.Journal of functional biomaterials · 2026Article
- Effect of Combined Equal-Channel Angular Pressing and Rolling on the Microstructure and Mechanical Properties of Zn-0.5Ag-0.2Mg Alloy.Materials (Basel, Switzerland) · 2025Article
- Machine learning-based optimization of cytotoxicity testing for assessing Zn-based biodegradable metals.Materials today. Bio · 2025Article
- Enhanced Experimental Setup and Methodology for the Investigation of Corrosion Fatigue in Metallic Biodegradable Implant Materials.Materials (Basel, Switzerland) · 2024Article
- Biocompatibility Assessment of Zinc Alloys as a New Potential Material for Bioabsorbable Implants for Osteosynthesis.Materials (Basel, Switzerland) · 2023Article
- Development, Processing and Aging of Novel Zn-Ag-Cu Based Biodegradable Alloys.Materials (Basel, Switzerland) · 2023Article
- Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review.Journal of functional biomaterials · 2023Review
- In vitro cytocompatibility and antibacterial studies on biodegradable Zn alloys supplemented by a critical assessment of direct contact cytotoxicity assay.Journal of biomedical materials research. Part B, Applied biomaterials · 2023Article
- Influence of Surface Roughness on Biodegradability and Cytocompatibility of High-Purity Magnesium.Materials (Basel, Switzerland) · 2022Article
- Improved biocompatibility of Zn-Ag-based stent materials by microstructure refinement.Acta biomaterialia · 2022Article
- Limitation of Water-Soluble Tetrazolium Salt for the Cytocompatibility Evaluation of Zinc-Based Metals.Materials (Basel, Switzerland) · 2021Article
- Appropriately adapted properties of hot-extruded Zn-0.5Cu-xFe alloys aimed for biodegradable guided bone regeneration membrane application.Bioactive materials · 2021Article
- Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials.Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Zinc (Zn) and Zn-based alloys have been proposed as a new generation of absorbable metals mainly owing to the moderate degradation behavior of zinc between magnesium and iron. Nonetheless, mechanical strength of pure Zn is relatively poor, making it insufficient for the majority of clinical applications. In this study, a novel Zn-2Ag-1.8Au-0.2V (wt.%) alloy (Zn-Ag-Au-V) was fabricated and investigated for use as a potential absorbable biocompatible material. Microstructural characterization indicated an effective grain-refining effect on the Zn alloy after a thermomechanical treatment. Compared to pure Zn, the Zn-Ag-Au-V alloy showed significantly enhanced mechanical properties, with a yield strength of 168 MPa, an ultimate tensile strength of 233 MPa, and an elongation of 17%. Immersion test indicated that the degradation rate of the Zn-Ag-Au-V alloy in Dulbecco's phosphate buffered saline was approximately 7.34 ± 0.64 μm/year, thus being slightly lower than that of pure Zn. Biocompatibility tests with L929 and Saos-2 cells showed a moderate cytotoxicity, alloy extracts at 16.7%, and 10% concentration did not affect metabolic activity and cell proliferation. Plaque formation in vitro was reduced, the Zn-Ag-Au-V surface inhibited adhesion and biofilm formation by the early oral colonizer
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