Evidence map›Paper›PMID 31861910›Full record

ArticleMolecules (Basel, Switzerland)2019

A Triazole Hybrid of Neolignans as a Potential Antileishmanial Agent by Triggering Mitochondrial Dysfunction.

Carla Cardozo Pinto de Arruda, Daiana de Jesus Hardoim, Yasmin Silva Rizk, Celeste da Silva Freitas de Souza, Tânia Zaverucha do Valle, Diego Bento Carvalho, Noemi Nosomi Taniwaki, Adriano Cesar de Morais Baroni, Kátia da Silva Calabrese

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carla Cardozo Pinto de ArrudaLaboratório de Parasitologia Humana, Instituto de Biociências, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brasil.ORCID 0000-0002-3106-781X
Daiana de Jesus HardoimLaboratório de Imunomodulação e Protozoologia (LIMP), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Rio de Janeiro, Brasil.
Yasmin Silva RizkLaboratório de Imunomodulação e Protozoologia (LIMP), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Rio de Janeiro, Brasil.
Celeste da Silva Freitas de SouzaLaboratório de Imunomodulação e Protozoologia (LIMP), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Rio de Janeiro, Brasil.
Tânia Zaverucha do ValleLaboratório de Imunomodulação e Protozoologia (LIMP), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Rio de Janeiro, Brasil.
Diego Bento CarvalhoLaboratório de Síntese e Química Medicinal (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brasil.
Noemi Nosomi TaniwakiNúcleo de Microscopia Eletrônica, Instituto Adolfo Lutz, 01246-000 São Paulo, São Paulo, Brasil.
Adriano Cesar de Morais BaroniLaboratório de Síntese e Química Medicinal (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, Mato Grosso do Sul, Brasil.
Kátia da Silva CalabreseLaboratório de Imunomodulação e Protozoologia (LIMP), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Rio de Janeiro, Brasil.ORCID 0000-0002-1884-3765

Funding

Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul 23/200.137/2010
6 · The paper itself

Abstract

In the search for new compounds with antileishmanial activity, we synthesized a triazole hybrid analogue of the neolignans grandisin and machilin G (LASQUIM 25), which was previously found highly active against both promastigotes and intracellular amastigote forms of

Indexed as

Antiprotozoal AgentsLignansTriazolesAnimalsLeishmania mexicanaMembrane Potential, MitochondrialMiceMice, Inbred BALB CMitochondriaAntiprotozoal AgentsLignansTriazolesantileishmanial activitycell deathLeishmania amazonensissynthetic derivativeultrastructure

Identifiers

PMID31861910
PMCPMC6983227

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.