Evidence map›Paper›PMID 31861863›Full record

ArticleInternational journal of molecular sciences2019

Synthetic Human β Defensin-3-C15 Peptide in Endodontics: Potential Therapeutic Agent in

Yeon-Jee Yoo, Hiran Perinpanayagam, Jue-Yeon Lee, Soram Oh, Yu Gu, A-Reum Kim, Seok-Woo Chang, Seung-Ho Baek, Kee-Yeon Kum

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Microorganisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Yeon-Jee YooDepartment of Conservative Dentistry, School of Dentistry, Dental Research Institute, Seoul National University, Daehak-ro 101, Chongno-Ku, Seoul 03080, Korea.
Hiran PerinpanayagamDepartment of Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0001-6484-5932
Jue-Yeon LeeCentral Research Institute, Nano intelligent Biomedical Engineering Corporation (NIBEC), Seoul 03130, Korea.ORCID 0000-0002-4914-1862
Soram OhDepartment of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.
Yu GuDepartment of Conservative Dentistry, School of Stomatology, Shandong University, Jinan 250012, China.
A-Reum KimDepartment of Oral Microbiology and Immunology, School of Dentistry, Dental Research Institute and BK21 Plus Program, Seoul National University, Seoul 08826, Korea.
Seok-Woo ChangDepartment of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.
Seung-Ho BaekDepartment of Conservative Dentistry, School of Dentistry, Dental Research Institute, Seoul National University, Daehak-ro 101, Chongno-Ku, Seoul 03080, Korea.
Kee-Yeon KumDepartment of Conservative Dentistry, School of Dentistry, Dental Research Institute, Seoul National University, Daehak-ro 101, Chongno-Ku, Seoul 03080, Korea.ORCID 0000-0002-3032-3498
Seoul National University · KRKyung Hee University · KRShandong University · CNWestern University · CA

Funding

Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and the Ministry of Health & Welfare HI17C1377Seoul National University Dental Hospital 04-2018-0102
6 · The paper itself

Abstract

Human β defensin-3-C15, an epithelium-derived cationic peptide that has antibacterial/antifungal and immuno-regulatory properties, is getting attention as potential therapeutic agent in endodontics. This study aimed to investigate if synthetic human β defensin-3-C15 (HBD3-C15) peptides could inhibit inflammatory responses in human dental pulp cells (hDPCs), which had been induced by gram-positive endodontic pathogen. hDPC explant cultures were stimulated with

Indexed as

Anti-Inflammatory Agentsbeta-DefensinsCells, CulturedDental PulpHumansInflammationLipoproteinsModels, MolecularStreptococcal InfectionsStreptococcus gordoniiAnti-Inflammatory Agentsbeta-DefensinsDEFB103A protein, humanLipoproteinscalcium hydroxidechemokinehuman beta defensin-3-C15human dental pulp cellStreptococcus gordonii lipoprotein

Identifiers

PMID31861863
PMCPMC6982004
OpenAlexW2995649599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.