Evidence map›Paper›PMID 31861850›Full record

ArticleViruses2019

The Zebrafish Xenograft Platform-A Novel Tool for Modeling KSHV-Associated Diseases.

Eric S Pringle, Jaime Wertman, Nicole Melong, Andrew J Coombs, Andrew L Young, David O'Leary, Chansey Veinotte, Carolyn-Ann Robinson, Michael N Ha, Graham Dellaire and 3 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. One Host-Multiple Applications: Zebrafish (International journal of molecular sciences · 2022
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Benefits of Zebrafish Xenograft Models in Cancer Research.Frontiers in cell and developmental biology · 2021
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Eric S PringleDepartment of Microbiology & Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.ORCID 0000-0003-3667-4595
Jaime WertmanDepartment of Microbiology & Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.
Nicole MelongCHEO Research Institute/Department of Pediatrics, University of Ottawa, Ottawa, ON K1H 8L1, Canada.
Andrew J CoombsDepartment of Pediatrics, Dalhousie University, 5980 University Ave, Halifax, NS B3K 6R8, Canada.
Andrew L YoungDivision of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
David O'LearyDivision of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chansey VeinotteDepartment of Microbiology & Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.
Carolyn-Ann RobinsonDepartment of Microbiology & Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.
Michael N HaDepartment of Radiation Oncology, 5820 University Ave, Halifax, NS B3H 1V7, Canada.
Graham DellaireBeatrice Hunter Cancer Research Institute, 5850 College Street, Halifax, NS B3H 4R2, Canada.ORCID 0000-0002-3466-6316
Todd E DruleyDivision of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-3245-7561
Craig McCormickDepartment of Microbiology & Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.ORCID 0000-0003-2794-3722
Jason N BermanDepartment of Microbiology & Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.
Dalhousie University · CAWashington University in St. Louis · USCanadian Bioethics Society · CAUniversity of Ottawa · CA

Funding

CIHR MOP-84554
6 · The paper itself

Abstract

Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy driven by aberrant proliferation of latently infected B lymphocytes, and supported by pro-inflammatory cytokines and angiogenic factors produced by cells that succumb to lytic viral replication. Here, we report the development of the first

Indexed as

Disease SusceptibilityAnimalsCell Line, TumorCell ProliferationDisease Models, AnimalHerpesviridae InfectionsHerpesvirus 8, HumanHeterograftsHumansSarcoma, KaposiZebrafishddPCRhuman herpesvirus-8hypoxiaKaposi’s sarcoma-associated herpesvirus (KSHV)primary effusion lymphoma (PEL)xenotransplantationzebrafish

Identifiers

PMID31861850
PMCPMC7019925
OpenAlexW2984486231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.