Evidence map›Paper›PMID 31861777›Full record

Trial reportMolecules (Basel, Switzerland)2019

Glycomic Signatures of Plasma IgG Improve Preoperative Prediction of the Invasiveness of Small Lung Nodules.

Xia Zou, Feng Yao, Fang Yang, Fang Zhang, Zhijue Xu, Jingjing Shi, Atsushi Kuno, Heng Zhao, Yan Zhang

Abstract readClinical Trial
In one paragraph

Trial report in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Databases and Bioinformatic Tools for Glycobiology and Glycoproteomics.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xia ZouKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Feng YaoDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Fang YangKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Fang ZhangKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhijue XuKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Jingjing ShiKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Atsushi KunoBiotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8568, Japan.ORCID 0000-0002-6147-6171
Heng ZhaoDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Yan ZhangKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Funding

National High Technology Research and Development Program of China 2012AA020203National Natural Science Foundation of China 31570796, 31770850 and 81802100National Science and Technology Major Project of China 2018ZX10302205Shanghai Chest Hospital Project of Collaborative Innovation YJXT20190208Shanghai Jiao Tong University Interdiscipline with Medicine Program YG2015ZD14, YG2017MS63 and YG2016QN58Shanghai Sailing Program 18YF1410500
6 · The paper itself

Abstract

Preoperative assessment of tumor invasiveness is essential to avoid overtreatment for patients with small-sized ground-glass nodules (GGNs) of 10 mm or less in diameter. However, it is difficult to determine the pathological state by computed tomography (CT) examination alone. Aberrant glycans has emerged as a tool to identify novel potential disease biomarkers. In this study, we used a lectin microarray-based strategy to investigate whether glycosylation changes in plasma immunoglobulin G (IgG) provide additional information about the invasiveness of small GGNs before surgery. Two independent cohorts (discovery set,

Indexed as

AgedBiomarkers, TumorFemaleGlycomicsGlycoproteinsHumansImmunoglobulin GLung NeoplasmsMaleMiddle AgedNeoplasm ProteinsPolysaccharidesBiomarkers, TumorGlycoproteinsglycosylated IgGImmunoglobulin GNeoplasm ProteinsPolysaccharidesglycobiomarkerground glass nodule (GGN)immunoglobulin G (IgG)lectin microarraymultilectin assay

Identifiers

PMID31861777
PMCPMC6982969

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.