Evidence map›Paper›PMID 31861744›Full record

ArticleInternational journal of molecular sciences2019

Biocatalytic Amplification of UV Signal in Capillary Electrophoresis of MicroRNA.

Ruibin Hu, Yi Chen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Progress of highly reproducible capillary electrophoresis].Se pu = Chinese journal of chromatography · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruibin HuKey Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yi ChenKey Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Funding

National Natural Science Foundation of China 21621062National Natural Science Foundation of China 21727809the Chinese Academy of Sciences QYZDJ-SSW-SLH034
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are new potential biomarkers for early diagnosis and classification of cancer. This study is the first attempt to use biocatalytic amplification reactions combined with capillary electrophoresis to detect multiple miRNAs simultaneously. In this way, miRNAs, as catalysts, can catalyze two single strands of DNA to form double-strand DNA. Feasibility was demonstrated by non-gel capillary electrophoresis coupled with UV detection (NGCE-UV). The detection limit was improved down to 1.0 nM, having ca. 10

Indexed as

BiocatalysisBiomarkers, TumorEarly Detection of CancerElectrophoresis, CapillaryFeasibility StudiesHumansLimit of DetectionMicroRNAsNeoplasmsNucleic Acid Amplification TechniquesUltraviolet RaysBiomarkers, TumorMicroRNAsdeterminationDNA hybridizationmicroRNA catalysisnon-gel capillary electrophoresisUV signal non-PCR amplification

Identifiers

PMID31861744
PMCPMC6981575

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.