Evidence map›Paper›PMID 31861703›Full record

ReviewBiomolecules2019

Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5.

Zefeng Zhao, Songsong Ruan, Xiaoming Ma, Qian Feng, Zhuosong Xie, Zhuang Nie, Peinan Fan, Mingcheng Qian, Xirui He, Shaoping Wu and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Zefeng ZhaoKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Songsong RuanKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Xiaoming MaKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Qian FengKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Zhuosong XieKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Zhuang NieKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Peinan FanKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Mingcheng QianDepartment of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China.
Xirui HeDepartment of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China.
Shaoping WuKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Yongmin ZhangKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Xiaohui ZhengKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an 710069, China.
Ministry of Education of the People's Republic of China · CNCentre National de la Recherche Scientifique · FRGhent University · BEZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The voltage-gated potassium channel Kv1.5, which mediates the cardiac ultra-rapid delayed-rectifier (I

Indexed as

AnimalsAtrial FibrillationHumansKv1.5 Potassium ChannelPotassiumProtein IsoformsSmall Molecule LibrariesStructure-Activity RelationshipKv1.5 Potassium ChannelPotassiumProtein IsoformsSmall Molecule LibrariesKCNA5Kv1.5modulatorspotassium channelSAR

Identifiers

PMID31861703
PMCPMC7022446
OpenAlexW2994742419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.