Evidence map›Paper›PMID 31861674›Full record

ArticleCells2019

Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca

Juan Moreno-Felici, Petra Hyroššová, Marc Aragó, Sergio Rodríguez-Arévalo, Pablo M García-Rovés, Carmen Escolano, Jose C Perales

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. iScience · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. eLife · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. The Crucial Roles of Intermediate Metabolites in Cancer.Cancer management and research · 2021
    Review
  19. Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation.International journal of molecular sciences · 2020
    Review
  20. The Two-Way Relationship Between Calcium and Metabolism in Cancer.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Juan Moreno-FeliciDepartment of Physiological Sciences, School of Medicine, University of Barcelona, Feixa Llarga s/n, 08907 L'Hospitalet del Llobregat, Barcelona, Spain.
Petra HyroššováDepartment of Physiological Sciences, School of Medicine, University of Barcelona, Feixa Llarga s/n, 08907 L'Hospitalet del Llobregat, Barcelona, Spain.
Marc AragóDepartment of Physiological Sciences, School of Medicine, University of Barcelona, Feixa Llarga s/n, 08907 L'Hospitalet del Llobregat, Barcelona, Spain.
Sergio Rodríguez-ArévaloLaboratory of Medicinal Chemistry (Associated Unit to CSIC), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain.
Pablo M García-RovésDepartment of Physiological Sciences, School of Medicine, University of Barcelona, Feixa Llarga s/n, 08907 L'Hospitalet del Llobregat, Barcelona, Spain.
Carmen EscolanoLaboratory of Medicinal Chemistry (Associated Unit to CSIC), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain.
Jose C PeralesDepartment of Physiological Sciences, School of Medicine, University of Barcelona, Feixa Llarga s/n, 08907 L'Hospitalet del Llobregat, Barcelona, Spain.
Universitat de Barcelona · ESInstitut d'Investigació Biomédica de Bellvitge · ES

Funding

Ministerio de Ciencia y Tecnología BFU2015-6030-R
6 · The paper itself

Abstract

Changes in phosphoenolpyruvate (PEP) concentrations secondary to variations in glucose availability can regulate calcium signaling in T cells as this metabolite potently inhibits the sarcoplasmic reticulum Ca

Indexed as

CalciumCalcium SignalingCell Line, TumorColonic NeoplasmsCyclooxygenase 2CytosolGene Expression Regulation, NeoplasticGlycolysisHCT116 CellsHumansInterleukin-6NFATC Transcription FactorsPhosphoenolpyruvatePhosphoenolpyruvate Carboxykinase (ATP)Proto-Oncogene Proteins c-mycCalciumCyclooxygenase 2IL6 protein, humanInterleukin-6MYC protein, humanNFATC Transcription FactorsPCK2 protein, humanPhosphoenolpyruvatePhosphoenolpyruvate Carboxykinase (ATP)Proto-Oncogene Proteins c-mycPTGS2 protein, humancalciumCaMK2Gcancer metabolismcataplerosisc-MycNFATPCK2PEPCK-Mphosphoenolpyruvatephosphoenolpyruvate carboxykinasephosphoenolpyruvate carboxykinase (PEPCK)sarcoplasmic reticulum Ca2+/ATPase pump (SERCA)TCA cycle

Identifiers

PMID31861674
PMCPMC7017135
OpenAlexW2995832176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.