Evidence map›Paper›PMID 31861672›Full record

ArticlePharmaceutics2019

Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases.

Maria Chiara Cristiano, Francesca Froiio, Roberta Spaccapelo, Antonia Mancuso, Steven P Nisticò, Betty P Udongo, Massimo Fresta, Donatella Paolino

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 97 citations in OpenAlex.

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  14. Polysaccharide-Based Transdermal Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  15. Article
  16. Article
  17. Lipid-Based Nanovesicular Drug Delivery Systems.Nanomaterials (Basel, Switzerland) · 2021
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria Chiara CristianoDepartment of Experimental and Clinical Medicine, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", viale Europa, 88100 Catanzaro, Italy.
Francesca FroiioDepartment of Experimental and Clinical Medicine, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", viale Europa, 88100 Catanzaro, Italy.
Roberta SpaccapeloDepartment of Experimental Medicine, University of Perugia, Piazzale Lucio Severi n. 1, 06132 Perugia, Italy.ORCID 0000-0003-2100-6172
Antonia MancusoDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0002-0915-8643
Steven P NisticòDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", viale Europa, 88100 Catanzaro, Italy.
Betty P UdongoPincer Training and Research Institute, Plot 1127, Lukuli Zone 5 00256, Uganda.
Massimo FrestaDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", viale Europa, 88100 Catanzaro, Italy.
Donatella PaolinoDepartment of Experimental and Clinical Medicine, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0002-5223-9879
Magna Graecia University · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulforaphane is a multi-action drug and its anticancer activity is the reason for the continuous growth of attention being paid to this drug. Sulforaphane shows an in vitro antiproliferative activity against melanoma and other skin cancer diseases. Unfortunately, this natural compound cannot be applied in free form on the skin due to its poor percutaneous permeation determined by its physico-chemical characteristics. The aim of this investigation was to evaluate ethosomes

Indexed as

anticancer activityethosomes®human stratum corneumpercutaneous permeationsulphoraphanetransfersomes®

Identifiers

PMID31861672
PMCPMC7023209
OpenAlexW2994986765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.