ArticleJournal of clinical medicine2019
The Relationship between Sleep Bruxism Intensity and Renalase Concentration-An Enzyme Involved in Hypertension Development.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Sleep bruxism and pediatric obstructive sleep apnea: exploring their chronological overlap and clinical significance.Sleep & breathing = Schlaf & Atmung · 2025Article
- The Role of Renalase in Cardiovascular Disease: A Comprehensive Review of Its Molecular Biology, Genetic Associations, and Clinical Significance.Life (Basel, Switzerland) · 2025Review
- Cardiovascular Risk Profiles of Individuals with Bruxism: A Case-Control Study Using QRISK3 Scores.Cureus · 2025Article
- Arginase and ceruloplasmin activity in the serum of patients with polysomnography-detected sleep bruxism.Frontiers in neurology · 2025Article
- Relation Between Exposure to Tobacco Smoke Assessed by Serum Cotinine Concentration and Questionnaire Method, and Serum Renalase Concentration-the Importance of the Coexistence of Arterial Hypertension and Other Cardiovascular Diseases.Cardiovascular toxicology · 2024Article
- Global Prevalence of Sleep Bruxism and Awake Bruxism in Pediatric and Adult Populations: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Association between Psychological Distress and Possible, Probable, and Definite Sleep Bruxism-A Comparison of Approved Diagnostic Procedures.Journal of clinical medicine · 2024Article
- Coexistence of Cardiovascular Risk Factors and Blood Renalase Concentration.International journal of molecular sciences · 2023Article
- The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease.Cells · 2023Review
- Cardiovascular Implications of Sleep Bruxism-A Systematic Review with Narrative Summary and Future Perspectives.Journal of clinical medicine · 2021Review
- Recent updates on novel therapeutic targets of cardiovascular diseases.Molecular and cellular biochemistry · 2021Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesRenalase, a novel amine oxidase, is involved in the development of hypertension. Sleep bruxism (SB) is a sleep-related behavior characterized by rhythmic or non-rhythmic activity of the masticatory muscles, which leads to the mechanical wear of teeth, pain in the masticatory muscles, and disturbed sleep. Recent studies indicate that SB plays a role in increased blood pressure. Therefore, this study aimed to determine the relationship between sleep bruxism intensity and renalase concentration, which may help in the future to elucidate the pathogenesis of hypertension and other cardiovascular disorders. MATERIAL AND
methodsSB was evaluated in 87 adult patients using single-night diagnostic polysomnography with video and audio recordings, and the episodes of bruxism were scored according to the standards of the American Academy of Sleep Medicine. The levels of serum renalase were measured in the patients using enzyme-linked immunosorbent assay kits.
resultsSB (Bruxism Episode Index (BEI) ≥2) was diagnosed in 54% (n = 47) of the studied population, and the mean concentration of renalase was found to be decreased in the hypertensive group compared with the normotensive group (133.33 ± 160.71 vs 219.23 ± 220.58,
conclusionThere exists an association between renalase concentration and SB intensity, and further studies are needed to clarify the role of renalase in the pathogenesis of hypertension and other cardiovascular disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.