Evidence map›Paper›PMID 31861571›Full record

ArticleJournal of clinical medicine2019

NPC1 Deficiency in Mice is Associated with Fetal Growth Restriction, Neonatal Lethality and Abnormal Lung Pathology.

Jorge L Rodriguez-Gil, Dawn E Watkins-Chow, Laura L Baxter, Tadafumi Yokoyama, Patricia M Zerfas, Matthew F Starost, William A Gahl, May Christine V Malicdan, Forbes D Porter, Frances M Platt and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Organ Weights inInternational journal of molecular sciences · 2022
    Article
  6. Article
  7. Article
  8. The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Jorge L Rodriguez-GilGenomics, Development and Disease Section, Genetic Disease Research Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Dawn E Watkins-ChowGenomics, Development and Disease Section, Genetic Disease Research Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Laura L BaxterGenomics, Development and Disease Section, Genetic Disease Research Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Tadafumi YokoyamaSection of Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NHGRI, NIH, Bethesda, MD, 20892, USA.
Patricia M ZerfasOffice of Research Services, Division of Veterinary Resources, NIH, Bethesda, MD, 20892, USA.
Matthew F StarostOffice of Research Services, Division of Veterinary Resources, NIH, Bethesda, MD, 20892, USA.
William A GahlSection of Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NHGRI, NIH, Bethesda, MD, 20892, USA.
May Christine V MalicdanSection of Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NHGRI, NIH, Bethesda, MD, 20892, USA.
Forbes D PorterProgram in Developmental Endocrinology and Genetics, NICHD, NIH, Bethesda, MD, 20892, USA.
Frances M PlattDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
William J PavanGenomics, Development and Disease Section, Genetic Disease Research Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
National Human Genome Research Institute · USOffice of Research Services · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Oxford · GBUniversity of Wisconsin–Madison · US

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
NHGRI NIH HHS 3T32GM008692NIGMS NIH HHS T32 GM008692Wellcome Trust 202834/Z/16/Z
6 · The paper itself

Abstract

The rare lysosomal storage disorder Niemann-Pick disease type C1 (NPC1) arises from mutation of

Indexed as

lung surfactantLysosomal storage diseasesneonatal lethalityNiemann-Pick disease type CNPC1

Identifiers

PMID31861571
PMCPMC7019814
OpenAlexW2995694533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.