Evidence map›Paper›PMID 31861565›Full record

ArticleViruses2019

Denis de Castro Silva, Ednelza da Silva Graça Amoras, Tuane Carolina Ferreira Moura, Felipe Teixeira Lopes, Samara Tatielle Monteiro Gomes, Carlos A da Costa, Maísa Silva Sousa, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Maria Alice Freitas Queiroz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. International journal of molecular sciences · 2023
    Article
  4. Association of theViruses · 2022
    Article
  5. Article
  6. Pathogenesis of HTLV-1 infection and progression biomarkers: An overview.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Denis de Castro SilvaLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Ednelza da Silva Graça AmorasLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Tuane Carolina Ferreira MouraLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Felipe Teixeira LopesLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Samara Tatielle Monteiro GomesLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Carlos A da CostaLaboratory of Cellular and Molecular Biology, Tropical Medicine Center, Federal University of Pará, Belém 66.055-240, Brazil.
Maísa Silva SousaLaboratory of Cellular and Molecular Biology, Tropical Medicine Center, Federal University of Pará, Belém 66.055-240, Brazil.
Ricardo IshakLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Antonio Carlos Rosário VallinotoLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.ORCID 0000-0003-1135-6507
Maria Alice Freitas QueirozLaboratório de Virologia, Instituto de Ciências Biológica, Universidade Federal do Pará, Belém 66.075-110, Brazil.ORCID 0000-0003-2014-2770
Universidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) deregulates the immune system and cell cycle, resulting in loss of immune tolerance and disease, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Three prime repair exonuclease 1 (TREX1) maintains innate immune tolerance of the host and host-cell permissiveness to retroviral infections. TREX1 polymorphisms may influence the course of infection and autoimmune manifestations. The influence of TREX1 531C/T polymorphism was investigated in HTLV-1 infection and development of symptoms among 151 persons infected with HTLV-1 (32 HAM/TSP, 19 rheumatologic manifestations, two dermatitis, five more than one diagnosis, two probable HAM/TSP, and 91 asymptomatic individuals) and 100 uninfected persons in the control group. Polymorphism genotyping and proviral load quantification were performed by real-time polymerase chain reaction (PCR) and antinuclear antibodies (ANAs) were screened by an indirect immunofluorescence assay. No statistically significant difference was found in polymorphism genotype and allele frequencies between the infected and control groups. HAM/TSP patients showed higher frequency of TT genotype than asymptomatic persons (

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideViral LoadAllelesExodeoxyribonucleasesFemaleGene FrequencyGenetic Association StudiesGenotypeHost-Pathogen InteractionsHTLV-I InfectionsHumansHuman T-lymphotropic virus 1MalePhosphoproteinsExodeoxyribonucleasesPhosphoproteinsthree prime repair exonuclease 1ANAcytokinesHAM/TSPHTLV-1polymorphismproviral loadTREX1

Identifiers

PMID31861565
PMCPMC7019804
OpenAlexW2996358294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.