Evidence map›Paper›PMID 31861549›Full record

ArticleMolecules (Basel, Switzerland)2019

Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation.

Anan Yaghmur, Boi Vi Tran, Seyed Moein Moghimi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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  9. The effective natural compounds for inhibiting Cervical cancer.Medical oncology (Northwood, London, England) · 2021
    Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anan YaghmurDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
Boi Vi TranDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
Seyed Moein MoghimiSchool of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

Funding

Danish Natural Sciences Research Council (DanScatt) for SAXS experiments DanScattTeknologi og Produktion, Det Frie Forskningsråd DFF- 7017-00065
6 · The paper itself

Abstract

Owing to their unique structural features, non-lamellar liquid crystalline nanoparticles comprising cubosomes and hexosomes are attracting increasing attention as versatile investigative drug carriers.

backgroundDepending on their physiochemical characteristics, drug molecules on entrapment can modulate and reorganize structural features of cubosomes and hexosomes. Therefore, it is important to assess the effect of guest molecules on broader biophysical characteristics of non-lamellar liquid crystalline nanoparticles, since drug-induced architectural, morphological, and size modifications can affect the biological performance of cubosomes and hexosomes.

methodsWe report on alterations in morphological, structural, and size characteristics of nanodispersions composed from binary mixtures of glycerol monooleate and vitamin E on thymoquinone (a molecule with wide therapeutic potentials) loading.

resultsThymoquinone loading was associated with a slight increase in the mean hydrodynamic nanoparticle size and led to structural transitions from an internal biphasic feature of coexisting inverse cubic

conclusionsThese nanodispersions have the potential to accommodate thymoquinone and may be considered as promising platforms for the development of thymoquinone nanomedicines.

Indexed as

BenzoquinonesDrug CompoundingGlyceridesLiquid CrystalsMolecular StructureNanoparticlesParticle SizeVitamin EBenzoquinonesGlyceridesmonooleinthymoquinoneVitamin Edrug encapsulationinverse cubic Fd3m phaseinverse hexagonal phasemicellar cubosomesnanodispersionsnanoparticle tracking analysissynchrotron small-angle scattering

Identifiers

PMID31861549
PMCPMC6982919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.