Evidence map›Paper›PMID 31861547›Full record

ArticleJournal of clinical medicine2019

HCMV Infection in a Mesenchymal Stem Cell Niche: Differential Impact on the Development of NK Cells versus ILC3.

Ricarda Ising, Sandra Weinhold, Sabrina Bianca Bennstein, Albert Zimmermann, Özer Degistirici, Gesine Kögler, Roland Meisel, Hartmut Hengel, Jörg Timm, Markus Uhrberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Stem Cell Therapy and Innate Lymphoid Cells.Stem cells international · 2022
    Review
  8. Review
  9. EfficientFrontiers in immunology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ricarda IsingInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Düsseldorf, Medical Faculty, 40225 Düsseldorf, Germany.
Sandra WeinholdInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Düsseldorf, Medical Faculty, 40225 Düsseldorf, Germany.
Sabrina Bianca BennsteinInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Düsseldorf, Medical Faculty, 40225 Düsseldorf, Germany.
Albert ZimmermannInstitute of Virology, Heinrich Heine University, University Hospital of Düsseldorf, 40225 Düsseldorf, Germany.
Özer DegistiriciDivision of Pediatric Stem Cell Therapy, Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Medical Faculty, 40225 Düsseldorf, Germany.
Gesine KöglerInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Düsseldorf, Medical Faculty, 40225 Düsseldorf, Germany.ORCID 0000-0002-1688-6171
Roland MeiselDivision of Pediatric Stem Cell Therapy, Clinic for Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Medical Faculty, 40225 Düsseldorf, Germany.
Hartmut HengelInstitute of Virology, University Medical Center, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-3482-816X
Jörg TimmInstitute of Virology, Heinrich Heine University, University Hospital of Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0001-7799-3045
Markus UhrbergInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Düsseldorf, Medical Faculty, 40225 Düsseldorf, Germany.

Funding

Deutsche Forschungsgemeinschaft HE2526/9-1Deutsche Forschungsgemeinschaft UH91/7Deutsche Forschungsgemeinschaft UH91/8
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is highly prevalent in most populations worldwide and has a major influence on shaping the human immune system. Natural killer (NK) cells are important antiviral effectors that adapt to HCMV infection by expansion of virus-specific effector/memory cells. The impact of HCMV infection on the development of NK cells and innate lymphoid cells (ILC) in general is less well understood. In this context, we have recently established a novel in vitro platform to study human NK cell development in a stem cell niche based on human bone marrow-derived mesenchymal stem cells (MSC). Here, the system was modified by infecting MSC with HCMV to study the influence of virus infection on NK/ILC development. We show that cord blood-derived hematopoietic progenitor cells are successfully differentiated into mature CD56

Indexed as

Graft-versus-host diseaseHuman cytomegalovirusInnate lymphoid cellsMesenchymal stem cellsNatural killer cell development

Identifiers

PMID31861547
PMCPMC7027004

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.