Evidence map›Paper›PMID 31861446›Full record

ArticleAntibiotics (Basel, Switzerland)2019

Reduced Production of Bacterial Membrane Vesicles Predicts Mortality in ST45/USA600 Methicillin-Resistant

Somrita Dey, Smitha Gudipati, Christopher Giuliano, Marcus J Zervos, Jonathan M Monk, Richard Szubin, Sarah C J Jorgensen, George Sakoulas, Andrew D Berti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Bacterial Membrane Vesicles: Physiological Roles, Infection Immunology, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  3. Article
  4. Journal of extracellular vesicles · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Somrita DeyDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI 48201, USA.
Smitha GudipatiHenry Ford Hospital, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Christopher GiulianoDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI 48201, USA.
Marcus J ZervosHenry Ford Hospital, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Jonathan M MonkDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA.
Richard SzubinDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA.
Sarah C J JorgensenDepartment of Pharmacy, Mount Sinai Hospital, University Health Network, Toronto, ON M5G 1X5, Canada.
George SakoulasDivision of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA.
Andrew D BertiDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI 48201, USA.
Wayne State University · USMount Sinai Hospital · CASharp Memorial Hospital · US

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
National Institute of Allergy and Infectious Diseases 1-U01-AI124316-01
6 · The paper itself

Abstract

Immune biomarkers can stratify mortality risk in staphylococcal bacteremia. Microbial biomarkers may provide more consistent signals during early infection. We demonstrate that in ST45/USA600 bacteremia, bacterial membrane vesicle production in vitro predicts clinical mortality (773 vs. 116 RFU, survivors vs. decedents,

Indexed as

biomarkerclinical outcomemembrane vesiclesMRSAUSA600

Identifiers

PMID31861446
PMCPMC7168145
OpenAlexW2995566116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.