Evidence map›Paper›PMID 31861443›Full record

ArticleSensors (Basel, Switzerland)2019

Designing Silver Nanoparticles for Detecting Levodopa (3,4-Dihydroxyphenylalanine, L-Dopa) Using Surface-Enhanced Raman Scattering (SERS).

Rafael Jesus Gonçalves Rubira, Sabrina Alessio Camacho, Cibely Silva Martin, Jorge Ricardo Mejía-Salazar, Faustino Reyes Gómez, Robson Rosa da Silva, Osvaldo Novais de Oliveira Junior, Priscila Alessio, Carlos José Leopoldo Constantino

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rafael Jesus Gonçalves RubiraSchool of Technology and Applied Sciences, São Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil.
Sabrina Alessio CamachoSchool of Sciences, Humanities and Languages, São Paulo State University (UNESP), Assis 19806-900 SP, Brazil.
Cibely Silva MartinSchool of Technology and Applied Sciences, São Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil.
Jorge Ricardo Mejía-SalazarNational Institute of Telecommunications (Inatel), Santa Rita do Sapucaí 37540-000 MG, Brazil.
Faustino Reyes GómezSão Carlos Institute of Physics, University of São Paulo (USP), P.O. Box 369, São Carlos 13560-970 SP, Brazil.
Robson Rosa da SilvaSão Carlos Institute of Physics, University of São Paulo (USP), P.O. Box 369, São Carlos 13560-970 SP, Brazil.
Osvaldo Novais de Oliveira JuniorSão Carlos Institute of Physics, University of São Paulo (USP), P.O. Box 369, São Carlos 13560-970 SP, Brazil.
Priscila AlessioSchool of Technology and Applied Sciences, São Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil.
Carlos José Leopoldo ConstantinoSchool of Technology and Applied Sciences, São Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BRNational Institute of Telecommunications · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 305958/2018-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 422163/2018-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 429496/2018-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/14262-7Rede Nacional de Ensino e Pesquisa 01250.075413/2018-04
6 · The paper itself

Abstract

Detection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson's disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanospheres, AgNP; and nanoplates, AgNPL) to detect L-Dopa in the nanoparticle dispersions. The sensitivity of the L-Dopa SERS signal depended on both nanoparticle shape and L-Dopa concentration. The adsorption mechanisms of L-Dopa on the nanoparticles inferred from a detailed analysis of the Raman spectra allowed us to determine the chemical groups involved. For instance, at concentrations below/equivalent to the limit found in human plasma (between 10

Indexed as

Ag nanoparticlesL-Dopamultidimensional projectionsSERS

Identifiers

PMID31861443
PMCPMC6982777
OpenAlexW2995449464

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.