Evidence map›Paper›PMID 31861427›Full record

ArticleInternational journal of molecular sciences2019

GTP Binding is Necessary for the Activation of a Toxic Mutant Isoform of the Essential GTPase ObgE.

Liselot Dewachter, Babette Deckers, Ella Martin, Pauline Herpels, Sotirios Gkekas, Wim Versées, Natalie Verstraeten, Maarten Fauvart, Jan Michiels

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Identification of Substrates of Cytoplasmic Peptidyl-ProlylInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Liselot DewachterCentre of Microbial and Plant Genetics, KU Leuven-University of Leuven, Kasteelpark Arenberg 20 box 2460, B-3001 Leuven, Belgium.
Babette DeckersStructural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
Ella MartinCentre of Microbial and Plant Genetics, KU Leuven-University of Leuven, Kasteelpark Arenberg 20 box 2460, B-3001 Leuven, Belgium.
Pauline HerpelsCentre of Microbial and Plant Genetics, KU Leuven-University of Leuven, Kasteelpark Arenberg 20 box 2460, B-3001 Leuven, Belgium.
Sotirios GkekasStructural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
Wim VerséesStructural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
Natalie VerstraetenCentre of Microbial and Plant Genetics, KU Leuven-University of Leuven, Kasteelpark Arenberg 20 box 2460, B-3001 Leuven, Belgium.
Maarten FauvartCentre of Microbial and Plant Genetics, KU Leuven-University of Leuven, Kasteelpark Arenberg 20 box 2460, B-3001 Leuven, Belgium.
Jan MichielsCentre of Microbial and Plant Genetics, KU Leuven-University of Leuven, Kasteelpark Arenberg 20 box 2460, B-3001 Leuven, Belgium.
VIB-KU Leuven Center for Microbiology · BEVrije Universiteit Brussel · BEIMEC · BE

Funding

Belgian Federal Science Policy Office P7/28Fonds Wetenschappelijk Onderzoek G047122N, G0B2515N and G055517NKU Leuven C16/17/006Vrije Universiteit Brussel SRP34
6 · The paper itself

Abstract

Even though the Obg protein is essential for bacterial viability, the cellular functions of this universally conserved GTPase remain enigmatic. Moreover, the influence of GTP and GDP binding on the activity of this protein is largely unknown. Previously, we identified a mutant isoform of ObgE (the Obg protein of

Indexed as

Escherichia coli ProteinsGuanosine TriphosphateModels, MolecularMonomeric GTP-Binding ProteinsMutant ProteinsProtein BindingProtein ConformationProtein Interaction Domains and MotifsProtein IsoformsStructure-Activity RelationshipEscherichia coli ProteinsGuanosine TriphosphateMonomeric GTP-Binding ProteinsMutant ProteinsObgE protein, E coliProtein IsoformsEscherichia coliGTPaseGTP bindingObgObgE

Identifiers

PMID31861427
PMCPMC6982127
OpenAlexW2995982033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.