Evidence map›Paper›PMID 31861349›Full record

Trial reportNutrients2019

Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial.

Daisuke Furushima, Takuma Nishimura, Norikata Takuma, Ryo Iketani, Tomohito Mizuno, Yuji Matsui, Tohru Yamaguchi, Yu Nakashima, Shinji Yamamoto, Masanobu Hibi and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  10. The JAK/STAT signaling pathway: from bench to clinic.Signal transduction and targeted therapy · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Daisuke FurushimaDepartment of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Takuma NishimuraDepartment of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Norikata TakumaWhite Cross Nursing Home, Tokyo 189-0021, Japan.
Ryo IketaniDepartment of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Tomohito MizunoBiological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Yuji MatsuiBiological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Tohru YamaguchiHealth Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Yu NakashimaPersonal Healthcare Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Shinji YamamotoPersonal Healthcare Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Masanobu HibiBiological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Hiroshi YamadaDepartment of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Kao Corporation (Japan) · JPUniversity of Shizuoka · JPJapanese Red Cross College of Nursing · JP

Funding

Kao Corporation 17-321
6 · The paper itself

Abstract

Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test,

Indexed as

Health PersonnelAdultCatecholsFemaleHumansMaleMiddle AgedRespiratory Tract InfectionsTeaYoung AdultcatecholCatecholsTeaacute upper respiratory infectioncatechinsepigallocatechin gallateinfluenza like illnessrandomized controlled trial

Identifiers

PMID31861349
PMCPMC7019590
OpenAlexW2996201680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.