Evidence map›Paper›PMID 31861343›Full record

ArticleInternational journal of molecular sciences2019

Cadmium Pathways in Snails Follow a Complementary Strategy between Metallothionein Detoxification and Auxiliary Inactivation by Phytochelatins.

Martin Dvorak, Raimund Schnegg, Michael Niederwanger, Veronika Pedrini-Martha, Peter Ladurner, Herbert Lindner, Leopold Kremser, Reinhard Lackner, Reinhard Dallinger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Metals and metallothionein evolution in snails: a contribution to the concept of metal-specific functionality from an animal model group.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  3. Article
  4. The transfer ofScientific reports · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Martin DvorakInstitute of Zoology and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.
Raimund SchneggInstitute of Zoology and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.
Michael NiederwangerInstitute of Zoology and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.ORCID 0000-0002-7229-4146
Veronika Pedrini-MarthaInstitute of Zoology and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.ORCID 0000-0003-0941-8174
Peter LadurnerInstitute of Zoology and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.
Herbert LindnerInstitute of Clinical Biochemistry, Innsbruck Medical University, Biocenter, Innrain 80, A-6020 Innsbruck, Austria.ORCID 0000-0003-1262-9976
Leopold KremserInstitute of Clinical Biochemistry, Innsbruck Medical University, Biocenter, Innrain 80, A-6020 Innsbruck, Austria.
Reinhard LacknerInstitute of Zoology and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.ORCID 0000-0002-7256-7132
Reinhard DallingerInstitute of Zoology and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.
Universität Innsbruck · ATInnsbruck Medical University · AT

Funding

Austrian Science Fund DACH project No. I 1482-N28undefined <span style="color:gray;font-size:10px;">undefined</span> Grant No. 219267Universität Innsbruck doctorate scholarship No. 2017/2/Bio-3
6 · The paper itself

Abstract

Metal detoxification is crucial for animals to cope with environmental exposure. In snails, a pivotal role in protection against cadmium (Cd) is attributed to metallothioneins (MTs). Some gastropod species express, in a lineage-specific manner, Cd-selective MTs devoted exclusively to the binding and detoxification of this single metal, whereas other species of snails possess non-selective MTs, but still show a high tolerance against Cd. An explanation for this may be that invertebrates and in particular snails may also synthetize phytochelatins (PCs), originally known to be produced by plants, to provide protection against metal or metalloid toxicity. Here we demonstrate that despite the fact that similar mechanisms for Cd inactivation exist in snail species through binding of the metal to MTs, the actual detoxification pathways for this metal may follow different traits in a species-specific manner. In particular, this depends on the detoxification capacity of MTs due to their Cd-selective or non-specific binding features. In the terrestrial slug

Indexed as

Inactivation, MetabolicMetabolic Networks and PathwaysAmino Acid SequenceAminoacyltransferasesAnimalsCadmiumChromatography, High Pressure LiquidGene Expression ProfilingMetallothioneinPhytochelatinsSnailsSpecies SpecificityTranscriptomeAminoacyltransferasesCadmiumcadmium-binding proteinglutathione gamma-glutamylcysteinyltransferaseMetallothioneinPhytochelatinscadmium accumulationcadmium binding selectivitycadmium tolerancedetoxification capacityGastropodaMolluscaphytochelatin synthaseslugsnailspecificity

Identifiers

PMID31861343
PMCPMC6981842
OpenAlexW2995323533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.