Evidence map›Paper›PMID 31861333›Full record

ArticleInternational journal of molecular sciences2019

Tetrahydroquinoline-Isoxazole/Isoxazoline Hybrid Compounds as Potential Cholinesterases Inhibitors: Synthesis, Enzyme Inhibition Assays, and Molecular Modeling Studies.

Yeray A Rodríguez Núñez, Margarita Gutíerrez, Jans Alzate-Morales, Francisco Adasme-Carreño, Fausto M Güiza, Cristian C Bernal, Arnold R Romero Bohórquez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 30 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yeray A Rodríguez NúñezLaboratorio Síntesis Orgánica, Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca 3460000, Chile.ORCID 0000-0003-4935-876X
Margarita GutíerrezLaboratorio Síntesis Orgánica, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca 3460000, Chile.
Jans Alzate-MoralesCenter for Bioinformatics, Simulations and Modeling, Faculty of Engineering, University of Talca, 2 Norte 685, Casilla 721, Talca 3460000, Chile.ORCID 0000-0001-9624-7849
Francisco Adasme-CarreñoCenter for Bioinformatics, Simulations and Modeling, Faculty of Engineering, University of Talca, 2 Norte 685, Casilla 721, Talca 3460000, Chile.ORCID 0000-0003-0971-9081
Fausto M GüizaGrupo de Investigación de Compuestos Orgánicos de Interés Medicinal (CODEIM), Parque Tecnológico Guatiguará, Universidad Industrial de Santander, A.A. 678, Piedecuesta 681011, Colombia.
Cristian C BernalGrupo de Investigación de Compuestos Orgánicos de Interés Medicinal (CODEIM), Parque Tecnológico Guatiguará, Universidad Industrial de Santander, A.A. 678, Piedecuesta 681011, Colombia.
Arnold R Romero BohórquezGrupo de Investigación de Compuestos Orgánicos de Interés Medicinal (CODEIM), Parque Tecnológico Guatiguará, Universidad Industrial de Santander, A.A. 678, Piedecuesta 681011, Colombia.
University of Talca · CLIndustrial University of Santander · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 44 hybrid compounds that included in their structure tetrahydroquinoline (THQ) and isoxazole/isoxazoline moieties were synthesized through the 1,3-dipolar cycloaddition reaction (1,3-DC) from the corresponding

Indexed as

AcetylcholinesteraseBinding SitesCatalytic DomainChemistry Techniques, SyntheticCholinesterase InhibitorsEnzyme ActivationHumansHydrogen BondingIsoxazolesKineticsMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein BindingQuinolinesStructure-Activity Relationship1,2,3,4-tetrahydroquinolineAcetylcholinesteraseCholinesterase InhibitorsIsoxazolesQuinolinesAlzheimer’s diseasecholinesterase inhibitorscross-docking and MM/GBSA free binding energyhybrid compounds

Identifiers

PMID31861333
PMCPMC6981637
OpenAlexW2996474882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.