ReviewPlants (Basel, Switzerland)2019
Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables.
Review in Plants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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Who cites it
59 citing papers in PubMed, 153 citations in OpenAlex.
- Trial
- Pharmacological insights into the antidiabetic potential ofToxicology reports · 2026Article
- From Traditional Spice to Functional Ingredient: Phenolic Profile and Bioactive Properties of Sicilian Rhus coriaria L. Fruit.Chemistry & biodiversity · 2026Article
- Toxicological profile of anti-diabetic drugs and emerging measures to reduce the toxic burden.Toxicology reports · 2026Review
- Identification of α-glucosidase inhibitory phytochemicals from Erythrina crista-galli using combined experimental and computational methods.BMC chemistry · 2026Article
- Macroalgal Peptides with Predicted α-Glucosidase Inhibitory Activity: Preparation and Molecular Docking.Marine drugs · 2026Article
- Polyphenolic Profile and Antioxidant and Aortic Endothelium Effect ofPlants (Basel, Switzerland) · 2026Article
- Berries fromPlants (Basel, Switzerland) · 2025Article
- Impact of the Food Matrix on the Antioxidant and Hypoglycemic Effects of Betalains from Red Prickly Pear Juice After In Vitro Digestion.Foods (Basel, Switzerland) · 2025Article
- Redox-Modulating Capacity and Effect of Ethyl Acetate Roots and Aerial Parts Extracts fromPlants (Basel, Switzerland) · 2025Article
- Unlocking nature's antidiabetic potential: computer-aided discovery of α-amylase and α-glucosidase inhibitors inIn silico pharmacology · 2025Article
- Article
- Bioactivity Evaluation and Phytochemical Characterization ofBiomedicines · 2024Article
- Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition.Molecules (Basel, Switzerland) · 2024Article
- Pharmacophore-based 3D-QSAR modeling, virtual screening, docking, molecular dynamics and biological evaluation studies for identification of potential inhibitors of alpha-glucosidase.Journal of molecular modeling · 2024Article
- In Vitro Inhibition of Enzymes and Antioxidant and Chemical Fingerprinting Characteristics ofPlants (Basel, Switzerland) · 2024Article
- Hypoglycemic Ability of Sericin-Derived Oligopeptides (SDOs) fromFoods (Basel, Switzerland) · 2024Article
- Phytochemistry, nutritional composition, health benefits and future prospects ofFood chemistry: X · 2024Review
- Comparative study on the effects of grain blending on functional compound content and in vitro biological activity.Scientific reports · 2024Article
- The Browning Properties, Antioxidant Activity, and α-Glucosidase Inhibitory Improvement of Aged Oranges (Foods (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Type-2 diabetes mellitus is one of the most prevalent metabolic diseases in the world, and is characterized by hyperglycemia (i.e., high levels of glucose in the blood). Alpha-glucosidases are enzymes in the digestive tract that hydrolyze carbohydrates into glucose. One strategy that has been developed to treat type-2 diabetes is inhibition of the activity of alpha-glucosidases using synthetic drugs. However, these inhibitors are usually associated with gastrointestinal side effects. Therefore, the development of inhibitors from natural products offers an alternative option for the control of hyperglycemia. In recent years, various studies have been conducted to identify alpha-glucosidases inhibitors from natural sources such as plants, and many candidates have transpired to be secondary metabolites including alkaloids, flavonoids, phenols, and terpenoids. In this review, we focus on the alpha-glucosidases inhibitors found in common vegetable crops and the major classes of phytochemicals responsible for the inhibitory activity, and also as potential/natural drug candidates for the treatment of type-2 diabetes mellitus. In addition, possible breeding strategies for production of improved vegetable crops with higher content of the inhibitors are also described.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.