Evidence map›Paper›PMID 31861222›Full record

ArticleMolecules (Basel, Switzerland)2019

Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T

Paul Mathieu, Yannick Coppel, Marc Respaud, Quyen T Nguyen, Sébastien Boutry, Sophie Laurent, Dimitri Stanicki, Céline Henoumont, Fernando Novio, Julia Lorenzo and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Magnetic Cell Targeting for Cardiovascular Tissue Engineering.Tissue engineering. Part B, Reviews · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Imaging Constructs: The Rise of Iron Oxide Nanoparticles.Molecules (Basel, Switzerland) · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paul MathieuCNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France.
Yannick CoppelCNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France.
Marc RespaudLPCNO, INSA, 135 Avenue de Rangueil, 31077 Toulouse CEDEX 4, France.
Quyen T NguyenCNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France.
Sébastien BoutryDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 19 avenue Maistriau, B- 7000 Mons, Belgium.
Sophie LaurentDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 19 avenue Maistriau, B- 7000 Mons, Belgium.
Dimitri StanickiDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 19 avenue Maistriau, B- 7000 Mons, Belgium.
Céline HenoumontDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 19 avenue Maistriau, B- 7000 Mons, Belgium.
Fernando NovioDepartament de Química, Universitat Autònoma de Barcelona (UAB), Campus UAB, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Julia LorenzoInstitut de Biotecnologia i Biomedicina, Departament de Bioquimica i de Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain.
David MontpeyóInstitut de Biotecnologia i Biomedicina, Departament de Bioquimica i de Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain.
Catherine AmiensCNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France.

Funding

Région Occitanie ESR_R&S_DF-000003/2017-006704Spanish Ministry of Sciences, Innovation and Universities RTI2018-098027-B-C22
6 · The paper itself

Abstract

The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates the search for less toxic and more effective alternatives. Among these alternatives, iron-iron oxide (Fe@FeOx) core-shell architectures have been long recognized as promising MRI contrast agents while limited information on their engineering is available. Here we report the synthesis of 10 nm large Fe@FeOx nanoparticles, their coating with a 11 nm thick layer of dense silica and functionalization by 5 kDa PEG chains to improve their biocompatibility. The nanomaterials obtained have been characterized by a set of complementary techniques such as infra-red and nuclear magnetic resonance spectroscopies, transmission electron microscopy, dynamic light scattering and zetametry, and magnetometry. They display hydrodynamic diameters in the 100 nm range, zetapotential values around -30 mV, and magnetization values higher than the reference contrast agent RESOVIST

Indexed as

Magnetic Resonance ImagingSilicon DioxideCell Line, TumorCoated Materials, BiocompatibleDextransFerric CompoundsHumansIronMagnetite NanoparticlesModels, TheoreticalSpectroscopy, Fourier Transform InfraredCoated Materials, BiocompatibleDextransFerric Compoundsferric oxideferumoxidesIronMagnetite NanoparticlesSilicon DioxideMRInanochemistrynanomaterialssurface functionalizationtoxicity

Identifiers

PMID31861222
PMCPMC6943426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.