Evidence map›Paper›PMID 31861129›Full record

ArticleInternational journal of molecular sciences2019

The Ubiquitin Proteasome System in Ischemic and Dilated Cardiomyopathy.

Sabine Spänig, Kristina Kellermann, Maja-Theresa Dieterlen, Thilo Noack, Sven Lehmann, Michael A Borger, Jens Garbade, Yaron D Barac, Fabian Emrich

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sabine SpänigDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.
Kristina KellermannDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.
Maja-Theresa DieterlenDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.
Thilo NoackDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.
Sven LehmannDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.
Michael A BorgerDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.
Jens GarbadeDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.ORCID 0000-0002-9239-2341
Yaron D BaracThe Cardiothoracic Surgery Department, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0002-4688-2358
Fabian EmrichDepartment of Cardiac Surgery, Heart Center Leipzig, University Leipzig, 04289 Leipzig, Germany.
Leipzig Heart Institute · DETel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dilated (DCM) and ischemic cardiomyopathies (ICM) are associated with cardiac remodeling, where the ubiquitin-proteasome system (UPS) holds a central role. Little is known about the UPS and its alterations in patients suffering from DCM or ICM. The aim of this study is to characterize the UPS activity in human heart tissue from cardiomyopathy patients. Myocardial tissue from ICM (

Indexed as

ApoptosisCardiomyopathy, DilatedHumansIschemiaMyocardiumNADPH OxidasesOxidative StressProteasome Endopeptidase ComplexProteostasisUbiquitinUbiquitin-Protein LigasesNADPH OxidasesProteasome Endopeptidase ComplexUbiquitinUbiquitin-Protein Ligasescardiac remodelingdilated cardiomyopathyE3 ligasesischemic cardiomyopathyprotein ubiquitinationubiquitin proteasome system

Identifiers

PMID31861129
PMCPMC6940920
OpenAlexW2996391461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.