Evidence map›Paper›PMID 31861110›Full record

ArticlePharmaceuticals (Basel, Switzerland)2019

Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-

Corinne Fruit, Florence Couly, Rahul Bhansali, Malini Rammohan, Mattias F Lindberg, John D Crispino, Laurent Meijer, Thierry Besson

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. 29th Annual GP2A Medicinal Chemistry Conference.Pharmaceuticals (Basel, Switzerland) · 2021
    Article
  3. Article
  4. Diabetic Kinome Inhibitors-A New Opportunity for β-Cells Restoration.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Corinne FruitNormandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France.ORCID 0000-0002-2878-4885
Florence CoulyNormandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France.
Rahul BhansaliDepartment of Medicine, Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-3616-7393
Malini RammohanDepartment of Medicine, Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.
Mattias F LindbergManRos Therapeutics & Perha Pharmaceuticals, Perharidy Peninsula, 29680 Roscoff, France.
John D CrispinoDepartment of Medicine, Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.
Laurent MeijerManRos Therapeutics & Perha Pharmaceuticals, Perharidy Peninsula, 29680 Roscoff, France.
Thierry BessonNormandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France.ORCID 0000-0003-3025-6659
Centre National de la Recherche Scientifique · FRNorthwestern University · USManRos Therapeutics (France) · FR

Funding

CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4M
NCI NIH HHS T32 CA009560
6 · The paper itself

Abstract

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) hyperactivity has been linked to the development of a number of human malignancies. DYRK1A is the most studied family member, and the discovery of novel specific inhibitors is attracting considerable interest. The 8-cyclopropyl-2(pyridin-3-yl)thiazolo[5,4-

Indexed as

CMGC kinasesDYRK family kinasespre-B cellsquiescenceSH-SY5Y-Tau-4R cellsthiazolo[5,4-f]quinazolin-9(8H)-one

Identifiers

PMID31861110
PMCPMC6958357
OpenAlexW2995963445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.