Evidence map›Paper›PMID 31861046›Full record

ArticlePathogens (Basel, Switzerland)2019

Development of Monoclonal Antibody Specific to Foot-and-Mouth Disease Virus Type A for Serodiagnosis.

Quyen Thi Nguyen, Jihyun Yang, Jae-Won Byun, Hyun Mi Pyo, Mi-Young Park, Bok Kyung Ku, Jinju Nah, Soyoon Ryoo, Sung-Hwan Wee, Kang-Seuk Choi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Quyen Thi NguyenInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Jihyun YangInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.ORCID 0000-0002-1935-8542
Jae-Won ByunFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Hyun Mi PyoFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Mi-Young ParkFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Bok Kyung KuFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Jinju NahFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Soyoon RyooFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Sung-Hwan WeeFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Kang-Seuk ChoiFoot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Gyongsangbuk-do 39660, Korea.
Haryoung PooInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Animal and Plant Quarantine Agency · KRKorea Research Institute of Bioscience and Biotechnology · KR

Funding

MOLECULAR CHARACTERIZATION OF MYELOMONOCYTIC LEUKEMIAK11CA001602 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MASTRIANNI, DAVID M · 1991 to 1995
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Korea Research Institute of Bioscience and Biotechnology Research Initiative ProgramNational Research Council of Science and Technology CAP-16-02-KIST
6 · The paper itself

Abstract

Foot-and-mouth disease (FMD) is a highly contagious and economically devastating disease affecting cloven-hoofed livestock worldwide. FMD virus (FMDV) type A is one of the most common causes of FMD outbreaks among the seven FMDV serotypes, and its serological diagnosis is therefore important to confirm FMDV type A infection and to determine FMD vaccine efficacy. Here, we generated monoclonal antibodies (mAbs) specific to FMDV type A via hybridoma systems using an inactivated FMDV type A (A22/Iraq/1964) and found 4 monoclones (#29, #106, #108, and #109) with high binding reactivity to FMDV type A among 594 primary clones. In particular, the #106 mAb had a higher binding reactivity to the inactivated FMDV type A than the other mAbs and a commercial mAb. Moreover, the #106 mAb showed no cross-reactivity to inactivated FMDV type South African territories 1, 2, and 3, and low reactivity to inactivated FMDV type O (O

Indexed as

foot-and-mouth diseasemonoclonal antibodysensitivitysolid-phase competitive ELISAstructural proteintype A

Identifiers

PMID31861046
PMCPMC6963590
OpenAlexW2994909796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.