Evidence map›Paper›PMID 31861040›Full record

SynthesisMedicine2019

The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis.

Lu Jin, Zhiguo An, Bin Xu, Daibin Mu, Songnian Fu, Hongxing Hu, Yongyong Shi, Xiao Luo, Qizhong Yi

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lu JinPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Zhiguo AnPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Bin XuPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Daibin MuPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Songnian FuPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Hongxing HuPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Yongyong ShiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, China.
Xiao LuoPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Qizhong YiPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang.
Xinjiang Medical University · CNFirst Affiliated Hospital of Xinjiang Medical University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe correlation between single nucleotide polymorphism (SNP) rs12807809 in Neurogranin (NRGN) gene and Schizophrenia (SCZ) was investigated by several studies, whereas the results were conflicting. Thus, we performed the present meta-analysis to combine and analyze the available studies in order to provide a more accurate result on the association of rs12807809 polymorphism in NRGN gene and SCZ vulnerability.

methodsA comprehensive retrieval in PubMed, EMBASE, Web of Science, Cochrane Library and Wanfang was performed for relevant studies on the relationship of rs12807809 polymorphism and SCZ. Summary odds ratios (OR) with 95% confidence interval (95% CI) were calculated in allelic, homozygous, heterozygous, dominant and recessive model to appraise the association.

resultsThe meta-analysis included 8 studies containing 12552 SCZ cases and 34783 controls. The results showed a statistically significant correlation between SCZ and rs12807809 polymorphism in overall population in allelic model (OR = 1.10, 95%CI 1.04-1.17). However, subgroup analysis indicated the association only existed in Caucasians but not Asian.

conclusionThe results of present meta-analysis suggested significant association between SNP rs12807809 in NRGN gene and SCZ susceptibility in Caucasians but not Asians.

Indexed as

Genetic Predisposition to DiseaseHumansNeurograninPolymorphism, Single NucleotideSchizophreniaNeurogranin

Identifiers

PMID31861040
PMCPMC6940187
OpenAlexW2996361878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.