Evidence map›Paper›PMID 31860767›Full record

ArticleAddiction (Abingdon, England)2020

Perceptions of extended-release buprenorphine injections for opioid use disorder among people who regularly use opioids in Australia.

Briony Larance, Louisa Degenhardt, Jason Grebely, Suzanne Nielsen, Raimondo Bruno, Paul Dietze, Kari Lancaster, Sarah Larney, Thomas Santo, Marian Shanahan and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Addiction (Abingdon, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Briony LaranceSchool of Psychology, University of Wollongong, Wollongong, NSW, Australia.ORCID 0000-0003-3800-7673
Louisa DegenhardtNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-8513-2218
Jason GrebelyKirby Institute, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-1833-2017
Suzanne NielsenNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0001-5341-1055
Raimondo BrunoNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0001-6673-833X
Paul DietzeBurnet Institute, Melbourne, Victoria, Australia.ORCID 0000-0001-7871-6234
Kari LancasterCentre for Social Research in Health, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-2411-7970
Sarah LarneyNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-5602-4963
Thomas SantoNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-1218-3946
Marian ShanahanNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0001-9873-3576
Sonja MemedovicNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-6003-7046
Robert AliNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0003-2905-8153
Michael FarrellNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0001-7008-8130
UNSW Sydney · AUBurnet Institute · AUUniversity of Tasmania · AUUniversity of Wollongong · AU

Funding

Using existing data to understand and ameliorate risk in opioid agonist therapyR01DA044170 · NIDA · UNIVERSITY OF NEW SOUTH WALES · PI DEGENHARDT, LOUISA · 2017 to 2019
$641k
NIDA NIH HHS R01 DA044170
6 · The paper itself

Abstract

aimsTo examine perceptions of extended-release (XR) buprenorphine injections among people who regularly use opioids in Australia.

designCross-sectional survey prior to implementation. XR-buprenorphine was registered in Australia in November 2018.

settingSydney, Melbourne and Hobart. Participants A total of 402 people who regularly use opioids interviewed December 2017 to March 2018. MEASUREMENTS: Primary outcome concerned the proportion of participants who believed XR-buprenorphine would be a good treatment option for them, preferred weekly versus monthly injections and perceived advantages/disadvantages of XR-buprenorphine. Independent variables concerned the demographic characteristics and features of current opioid agonist treatment (OAT; medication-type, dose, prescriber/dosing setting, unsupervised doses, out-of-pocket expenses and travel distance).

findingsSixty-eight per cent [95% confidence interval (CI) = 63-73%] believed XR-buprenorphine was a good treatment option for them. They were more likely to report being younger [26-35 versus > 55 years; odds ratio (OR) = 3.16, 95% CI = 1.12-8.89; P = 0.029], being female (OR = 1.67, 95% CI = 1.04-2.69; P = 0.034), < 10 years school education (OR = 1.87, 95% CI = 1.12-3.12; P = 0.016) and past-month heroin (OR = 1.81, 95% CI = 1.15-2.85; P = 0.006) and methamphetamine use (OR = 1.90, 95% CI = 1.20-3.01; P = 0.006). Fifty-four per cent reported no preference for weekly versus monthly injections, 7% preferred weekly and 39% preferred monthly. Among OAT recipients (n = 255), believing XR-buprenorphine was a good treatment option was associated with shorter treatment episodes (1-2 versus ≥ 2 years; OR = 3.93, 95% CI = 1.26-12.22; P = 0.018), fewer unsupervised doses (≤ 8 doses past-month versus no take-aways; OR = 0.50; 95% CI = 0.27-0.93; P = 0.028) and longer travel distance (≥ 5 versus < 5 km; OR = 2.10, 95% CI = 1.20-3.65; P = 0.009). Sixty-nine per cent reported 'no problems or concerns' with potential differences in availability, flexibility and location of XR-buprenorphine.

conclusionsAmong regular opioid users in Australia, perceptions of extended-release buprenorphine as a good treatment option are associated with being female, recent illicit drug use and factors relating to the (in)convenience of current opioid agonist treatment.

Indexed as

AdultAustraliaBuprenorphineCross-Sectional StudiesDelayed-Action PreparationsDrug UsersFemaleHumansInjections, SubcutaneousMaleMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPatient PreferenceBuprenorphineDelayed-Action PreparationsBuprenorphine depotbuprenorphine injectiondepot preparationsmedication-assisted treatmentopioiduse disorderpatient preferences

Identifiers

PMID31860767
PMCPMC7292758
OpenAlexW2995648337

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.