ArticlePloS one2019
Identification and characterization of compounds from Chrysosporium multifidum, a fungus with moderate antimicrobial activity isolated from Hermetia illucens gut microbiota.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Potential health benefits of insect bioactive metabolites and consumer attitudes towards edible insects.NPJ science of food · 2025Review
- Antimicrobial Compounds FromInternational journal of microbiology · 2025Article
- Black Soldier Fly (Animals : an open access journal from MDPI · 2024Article
- Microorganism Contribution to Mass-Reared Edible Insects: Opportunities and Challenges.Insects · 2024Review
- Nucleoside Analogs: A Review of Its Source and Separation Processes.Molecules (Basel, Switzerland) · 2023Review
- The Variety of Applications ofBiology · 2022Review
- In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases.European journal of pharmacology · 2022Review
- Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review.RSC advances · 2022Review
- Diversity, antibacterial activity and chemical analyses of gut-associated fungi isolated from theFrontiers in microbiology · 2022Article
- Staphylococcus aureus in Substrates for Black Soldier Fly Larvae (Hermetia illucens) and Its Dynamics during Rearing.Microbiology spectrum · 2021Article
- An Overview of Antimicrobial Compounds from African Edible Insects and Their Associated Microbiota.Antibiotics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota of insects is composed of a wide range of microorganisms which produce bioactive compounds that protect their host from pathogenic attack. In the present study, we isolate and identify the fungus Chrysosporium multifidum from the gut of Hermetia illucens larvae. Extract from C. multifidum culture broth supernatant showed moderate activity against a strain of methicillin-resistant Staphylococcus aureus (MRSA). Bioguided isolation of the extract resulted in the characterization of six α-pyrone derivatives (1-6) and one diketopiperazine (7). Of these compounds, 5,6-dihydro-4-methoxy-6-(1-oxopentyl)-2H-pyran-2-one (4) showed the greatest activity (IC50 = 11.4 ± 0.7 μg/mL and MIC = 62.5 μg/mL) against MRSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.