Evidence map›Paper›PMID 31860304›Full record

ArticleJournal of natural products2020

Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from

Hua-Ding Zhao, Yan Lu, Min Yan, Chin-Ho Chen, Susan L Morris-Natschke, Kuo-Hsiung Lee, Dao-Feng Chen

Open access · greenAbstract read
In one paragraph

Article in Journal of natural products, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Identification of Daphnane Diterpenoids fromPlants (Basel, Switzerland) · 2023
    Article
  4. Review
  5. Identification ofMolecules (Basel, Switzerland) · 2023
    Article
  6. Lead/Drug Discovery from Natural Resources.Molecules (Basel, Switzerland) · 2022
    Review
  7. Daphnane-Type Diterpenes fromMolecules (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Hua-Ding ZhaoSchool of Pharmacy, Institutes of Integrative Medicine , Fudan University , Shanghai 201203 , People's Republic of China.
Yan LuSchool of Pharmacy, Institutes of Integrative Medicine , Fudan University , Shanghai 201203 , People's Republic of China.ORCID 0000-0002-9420-7090
Min YanSchool of Pharmacy, Institutes of Integrative Medicine , Fudan University , Shanghai 201203 , People's Republic of China.
Chin-Ho ChenDuke University Medical Center , Box 2926, SORF, Durham , North Carolina 27710 , United States.ORCID 0000-0001-6880-2104
Susan L Morris-NatschkeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , North Carolina 27599-7568 , United States.
Kuo-Hsiung LeeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , North Carolina 27599-7568 , United States.ORCID 0000-0002-6562-0070
Dao-Feng ChenSchool of Pharmacy, Institutes of Integrative Medicine , Fudan University , Shanghai 201203 , People's Republic of China.ORCID 0000-0003-3806-3114
Fudan University · CNUniversity of North Carolina at Chapel Hill · USDuke Medical Center · US

Funding

PLANT ANTIHIV AGENTSR01AI033066 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, KUO-HSIUNG · 1992 to 2018
$8.4M
NIAID NIH HHS R01 AI033066
6 · The paper itself

Abstract

Daphnane diterpenes with a 5/7/6-tricyclic ring system exhibit potent anti-HIV activity but are found in low abundance as plant natural products. In this study, an effective approach based on mass spectrometric fragmentation pathways was conducted to specifically recognize and isolate anti-HIV compounds of this type from

Indexed as

Chromatography, High Pressure LiquidChromatography, LiquidDaphneDiterpenesMagnetic Resonance SpectroscopyMolecular StructureTandem Mass SpectrometryDiterpenesmezerein

Identifiers

PMID31860304
PMCPMC7441572
OpenAlexW2996595903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.