ArticleCancer2020
Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study.
Article in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Older adult participation in cancer clinical trials: A systematic review of barriers and interventions.CA: a cancer journal for clinicians · 2021Pooled it
- The Efficacy of Reminiscence Therapy in Cancer-Related Symptom Management: A Systematic Review and Meta-Analysis.Integrative cancer therapiesPooled it
- Understanding the Effects of Cancer-Related Factors on the Association Between Physical Activity and Quality of Life in Breast Cancer Survivors.Journal of physical activity & health · 2026Trial
- Comparison of the effects of low- versus high-supervision exercise on breast cancer survivorship outcomes.JNCI cancer spectrum · 2026Trial
- Older breast cancer survivors' exercise and support group program experiences and recommendations from the IMPROVE trial: a qualitative study.BMC cancer · 2026Trial
- Effect of the Fit2Thrive Intervention on Patient-reported Outcomes in Breast Cancer Survivors: A Randomized Full Factorial Trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Trial
- Actigraphy-derived multidimensional sleep health among breast cancer survivors and controls: Pink SWAN.Journal of cancer survivorship : research and practice · 2026Article
- Uncovering the symptom relationship among sleep quality, anxiety, and depression in Chinese patients with breast cancer: multidimensional data validation using PSQI versus actigraphy.Journal of cancer survivorship : research and practice · 2026Article
- Survivorship Issues in Older Adults with Breast Cancer.Current breast cancer reports · 2025Article
- Longitudinal symptom network patterns in cancer patients during the end of life.Scientific reports · 2025Article
- Core preoperative symptoms and patients' symptom experiences in oral cancer: a mixed-methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Article
- Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Article
- Associations Between Rehabilitation Utilization and Out-of-Pocket Costs Among Older Adults With Breast Cancer in the United States.Archives of physical medicine and rehabilitation · 2024Article
- Effects of dietary habits and catheterization type on breast cancer-related lymphedema: a retrospective cohort study.BMC cancer · 2024Article
- Association between Cognitive Function and Physical Function, Frailty, and Quality of Life in Older Breast Cancer Survivors.Cancers · 2024Article
- The impact of non- and anthracycline-based chemotherapy on fatigue in breast cancer survivors: results from WF-97415.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Sleep disturbance among breast cancer survivors and controls from midlife to early older adulthood: Pink SWAN.Journal of cancer survivorship : research and practice · 2024Article
- Acute cancer-related symptoms and concerns among patients receiving chemotherapy: current state of the science.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
backgroundLittle is known about longitudinal symptom burden, its consequences for well-being, and whether lifestyle moderates the burden in older survivors.
methodsThe authors report on 36-month data from survivors aged ≥60 years with newly diagnosed, nonmetastatic breast cancer and noncancer controls recruited from August 2010 through June 2016. Symptom burden was measured as the sum of self-reported symptoms/diseases as follows: pain (yes or no), fatigue (on the Functional Assessment of Cancer Therapy [FACT]-Fatigue scale), cognitive (on the FACT-Cognitive scale), sleep problems (yes or no), depression (on the Center for Epidemiologic Studies Depression scale), anxiety (on the State-Trait Anxiety Inventory), and cardiac problems and neuropathy (yes or no). Well-being was measured using the FACT-General scale, with scores from 0 to 100. Lifestyle included smoking, alcohol use, body mass index, physical activity, and leisure activities. Mixed models assessed relations between treatment group (chemotherapy with or without hormone therapy, hormone therapy only, and controls) and symptom burden, lifestyle, and covariates. Separate models tested the effects of fluctuations in symptom burden and lifestyle on function.
resultsAll groups reported high baseline symptoms, and levels remained high over time; differences between survivors and controls were most notable for cognitive and sleep problems, anxiety, and neuropathy. The adjusted burden score was highest among chemotherapy-exposed survivors, followed by hormone therapy-exposed survivors versus controls (P < .001). The burden score was related to physical, emotional, and functional well-being (eg, survivors with lower vs higher burden scores had 12.4-point higher physical well-being scores). The composite lifestyle score was not related to symptom burden or well-being, but physical activity was significantly associated with each outcome (P < .005).
conclusionsCancer and its treatments are associated with a higher level of actionable symptoms and greater loss of well-being over time in older breast cancer survivors than in comparable noncancer populations, suggesting the need for surveillance and opportunities for intervention.
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