Evidence map›Paper›PMID 31860119›Full record

ArticleExperimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association2020

Shortened Fingers and Toes: GNAS Abnormalities are Not the Only Cause.

Monica Reyes, Caroline Silve, Harald Jüppner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. A novel mutation inBone reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Monica ReyesEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Caroline SilveINSERM équipe "Génomiques et épigénétique des tumeurs rares", Institut Cochin, Paris, France.
Harald JüppnerEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Assistance Publique – Hôpitaux de Paris · FRBoston Children's Hospital · USHarvard University · US

Funding

Tissue Phenotyping CoreP01DK011794 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BOUXSEIN, MARY L · 1986 to 2023
$44.4M
PTH/PTHRP RECEPTOR DEFECTS IN PSEUDOHYPOPARATHYROIDISMR01DK046718 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JUEPPNER, HARALD W. · 1993 to 2024
$6.0M
PTH Inverse Agonists as Therapy for Jansens DiseaseR01DK113039 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI THOMAS J GARDELLA, HARALD W. JUEPPNER · 2018 to 2026
$3.5M
NIDDK NIH HHS P01 DK011794NIDDK NIH HHS R01 DK046718NIDDK NIH HHS R01 DK113039
6 · The paper itself

Abstract

The PTH/PTHrP receptor (PTHR1) mediates the actions of parathyroid hormone (PTH) and PTH-related peptide (PTHrP) by coupling this G protein-coupled receptor (GPCR) to the alpha-subunit of the heterotrimeric stimulatory G protein (Gsα) and thereby to the formation of cAMP. In growth plates, PTHrP-dependent activation of the cAMP/PKA second messenger pathway prevents the premature differentiation of chondrocytes into hypertrophic cells resulting in delayed growth plate closure. Heterozygous mutations in

Indexed as

ChondrocytesChromograninsCyclic AMP-Dependent Protein Kinase RIalpha SubunitCyclic AMP-Dependent Protein KinasesCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4FingersGrowth PlateGTP-Binding Protein alpha Subunits, GsHumansMusculoskeletal AbnormalitiesParathyroid Hormone-Related ProteinReceptor, Parathyroid Hormone, Type 1ToesChromograninsCyclic AMP-Dependent Protein Kinase RIalpha SubunitCyclic AMP-Dependent Protein KinasesCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4GNAS protein, humanGTP-Binding Protein alpha Subunits, GsParathyroid Hormone-Related ProteinPDE3A protein, humanPDE4D protein, humanPRKAR1A protein, humanPTH1R protein, humanReceptor, Parathyroid Hormone, Type 1

Identifiers

PMID31860119
PMCPMC7950720
OpenAlexW2994633317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.