ArticleBrain : a journal of neurology2020
Spatial distribution of interictal spikes fluctuates over time and localizes seizure onset.
Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 101 citations in OpenAlex.
- The Influence of Recording Duration and Vigilance State on High-Frequency Oscillation Characterization in Epilepsy.Neurology · 2026Article
- Discovering Novel intracranial EEG Biomarkers of Seizure Generating Tissue through Time-Frequency Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Regional excitability, not epileptic pathology, drives stimulation-evoked interictal spike increases.medRxiv : the preprint server for health sciences · 2026Article
- Mapping intraoperative interictal epileptiform discharges using high-resolution, thin-film cortical arrays.Epilepsia · 2026Article
- Arterial spin labeling MRI with multiple post-labeling delays reveals interictal hypo- and hyper-perfusion patterns in epilepsy: A proof of concept.Journal of neuroradiology = Journal de neuroradiologie · 2026Article
- Predicting surgical outcome in drug-resistant epilepsy by combining interictal biomarkers within a machine learning framework.Scientific reports · 2026Article
- Predicting Surgical Outcome in Drug-Resistant Epilepsy by Combining Interictal Biomarkers within a Machine Learning Framework.Research square · 2026Article
- Synchrony is a robust iEEG biomarker for antiseizure medication load in epileptic patients.bioRxiv : the preprint server for biology · 2026Article
- Sleep increases firing rate modulation during interictal epileptiform discharges in mesial temporal structures.Brain communications · 2026Article
- Opposing interictal dynamics in Alzheimer's disease and epilepsy.Progress in neurobiology · 2026Article
- Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.Epilepsia · 2025Article
- Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones.Epilepsia · 2025Article
- Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study.Annals of neurology · 2025Article
- Multimodal quantitative analysis guides precise preoperative localization of epilepsy.Journal of neurology · 2025Review
- Predicting seizure onset zones from interictal intracranial EEG using functional connectivity and machine learning.Scientific reports · 2025Article
- Dataset of long-term multi-site LFP activity with spontaneous chronic seizures in temporal lobe epilepsy rats.Scientific data · 2025Article
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
- Co-activation of interictal epileptiform discharges localizes seizure onset zone and fluctuates with brain state.Brain communications · 2025Article
- Ictal phase-amplitude coupling as a biomarker for seizure onset zone in neocortical epilepsy.Frontiers in neurology · 2025Article
- Generalisability of epileptiform patterns across time and patients.Scientific reports · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The location of interictal spikes is used to aid surgical planning in patients with medically refractory epilepsy; however, their spatial and temporal dynamics are poorly understood. In this study, we analysed the spatial distribution of interictal spikes over time in 20 adult and paediatric patients (12 females, mean age = 34.5 years, range = 5-58) who underwent intracranial EEG evaluation for epilepsy surgery. Interictal spikes were detected in the 24 h surrounding each seizure and spikes were clustered based on spatial location. The temporal dynamics of spike spatial distribution were calculated for each patient and the effects of sleep and seizures on these dynamics were evaluated. Finally, spike location was assessed in relation to seizure onset location. We found that spike spatial distribution fluctuated significantly over time in 14/20 patients (with a significant aggregate effect across patients, Fisher's method: P < 0.001). A median of 12 sequential hours were required to capture 80% of the variability in spike spatial distribution. Sleep and postictal state affected the spike spatial distribution in 8/20 and 4/20 patients, respectively, with a significant aggregate effect (Fisher's method: P < 0.001 for each). There was no evidence of pre-ictal change in the spike spatial distribution for any patient or in aggregate (Fisher's method: P = 0.99). The electrode with the highest spike frequency and the electrode with the largest area of downstream spike propagation both localized the seizure onset zone better than predicted by chance (Wilcoxon signed-rank test: P = 0.005 and P = 0.002, respectively). In conclusion, spikes localize seizure onset. However, temporal fluctuations in spike spatial distribution, particularly in relation to sleep and post-ictal state, can confound localization. An adequate duration of intracranial recording-ideally at least 12 sequential hours-capturing both sleep and wakefulness should be obtained to sufficiently sample the interictal network.
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