ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2020
Chlorophyll treatment combined with photostimulation increases glycolysis and decreases oxidative stress in the liver of type 1 diabetic rats.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Exploring natural colorants from plants to insects: chemistry, functions, and modern uses.RSC advances · 2026Review
- Beyond Green: The Therapeutic Potential of Chlorophyll and Its Derivatives in Diabetes Control.Nutrients · 2025Review
- Chlorophylls as Natural Bioactive Compounds Existing in Food By-Products: A Critical Review.Plants (Basel, Switzerland) · 2023Review
- Plant Extracts in Obesity: A Role of Gut Microbiota.Frontiers in nutrition · 2021Review
- Carotenoids and Chlorophylls as Antioxidants.Antioxidants (Basel, Switzerland) · 2020Review
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
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Abstract
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditions such as T1DM, changes in liver metabolic pathways result in hyperglycemia, which is associated with multiple organic dysfunctions. In this context, it has been suggested that chlorophyll-a and its derivatives have anti-diabetic actions, such as reducing hyperglycemia, hyperinsulinemia, and hypertriglyceridemia, but these effects have not yet been proven. Thus, the biological action of PDT with chlorophyll-a on hepatic parameters related to energy metabolism and oxidative stress in T1DM Wistar rats was investigated. Evaluation of the acute effects of this pigment was performed by incubation of isolated hepatocytes with chlorophyll-a and the chronic effects were evaluated by oral treatment with chlorophyll-based extract, with post-analysis of the intact liver by in situ perfusion. In both experimental protocols, chlorophyll-a decreased hepatic glucose release and glycogenolysis rate and stimulated the glycolytic pathway in DM/PDT. In addition, there was a reduction in hepatic oxidative stress, noticeable by decreased lipoperoxidation, reactive oxygen species, and carbonylated proteins in livers of chlorophyll-treated T1DM rats. These are indicators of the potential capacity of chlorophyll-a in improving the status of the diabetic liver.
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