ArticleMemorias do Instituto Oswaldo Cruz2019
Erythrocytes morphology and hemorheology in severe bacterial infection.
Article in Memorias do Instituto Oswaldo Cruz, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Age-dependent neuroinflammatory effects of red blood cells and their exosomes in a human brain-on-chip model.Blood red cells & iron · 2026Article
- Phytomodulatory latex proteins improve blood homeostasis in diabetic mice with disseminated bacterial infection.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- SEMTWIST Quantification of Biofilm Infection in Human Chronic Wound Using Scanning Electron Microscopy and Machine Learning.Advances in wound care · 2025Article
- Red Blood Cell-Derived Exosomes as Mediators of Age-Related Neurodegeneration.Rejuvenation research · 2025Article
- Significance of Hemorheological Tests During Mycoplasma Pulmonis Infection in Laboratory Rats.Animals : an open access journal from MDPI · 2025Article
- When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients.BMC oral health · 2024Article
- Changes in Leukogram and Erythrogram Results in Bitches with Vaginitis.Animals : an open access journal from MDPI · 2021Article
- Anti-inflammatory latex proteins of the medicinal plant Calotropis procera: a promising alternative for oral mucositis treatment.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Latex proteins downregulate inflammation and restores blood-coagulation homeostasis in acute Salmonella infection.Memorias do Instituto Oswaldo Cruz · 2020Article
- Bone Marrow Erythroblastic Dysplasia on Morphology Correlates Significantly with Flow Cytometric Apoptosis and Peripheral Blood Eryptosis.Journal of microscopy and ultrastructureArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere bacterial infections initiate inadequate inflammation that leads to disseminated intravascular coagulation and death.
objectivesTo evaluate the influence of bacterial infection on blood viscosity and red blood cells (RBCs) morphology, and the ability of Calotropis procera proteins (CpLP) to prevent the patho-hemorheology in infected animals.
methodsRheology of blood, atomic force microscopy measurements on specific blood elements and blood count were performed to examine changes in blood viscosity, RBCs morphology, platelets activation, and RBCs indices.
findingsInfected mice hold their blood rheological behaviour as compared to that of the control group. However, they presented hyperactivated platelets, RBCs at different stages of eryptosis, and variation on RBCs indices. CpLP administration in healthy animals altered blood behaviour from pseudoplastic to Bingham-like fluid. Such effect disappeared over time and by inhibiting its proteases. No alterations were observed in RBCs morphology or platelets. Treatment of infected animals with CpLP prevented the changes in RBCs indices and morphology. MAIN
conclusionsThe inflammatory process triggered by bacterial infection induced pathological changes in RBCs and platelets activation. Treatment of infected animals with CpLP prevented the emergence of RBCs abnormal morphology and this may have implications in the protective effect of CpLP, avoiding animal death.
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