SynthesisJournal of medical Internet research2019
Digital Alerting and Outcomes in Patients With Sepsis: Systematic Review and Meta-Analysis.
Synthesis in Journal of medical Internet research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis.Journal of general internal medicine · 2025Pooled it
- Sepsis Alert Systems, Mortality, and Adherence in Emergency Departments: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Trial
- Sepsis Diagnostic Excellence: Development and Validation of a Theoretical Framework for Conceptualizing Accurate, Timely Sepsis Diagnosis.Critical care explorations · 2026Observational
- Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low-Intensity Pulsed Ultrasound and Imipenem.Mediators of inflammation · 2026Article
- Digital Transformation in Critical Care: Implications for Quality of Care, Infection Control, and Clinical Outcomes.Journal of clinical medicine · 2025Article
- Presenting a conceptual model for decision support systems in infertility: A developmental study.International journal of reproductive biomedicine · 2025Article
- Impact of the National Early Warning Score-based sepsis response system on hospital-onset sepsis in a tertiary hospital in South Korea.Acute and critical care · 2025Article
- Digital innovation in healthcare: quantifying the impact of digital sepsis screening tools on patient outcomes-a multi-site natural experiment.BMJ health & care informatics · 2025Article
- Assessing the Benefit of a Digital Pain Alert System in a Community Hospital.Journal of pain research · 2025Article
- Epigenetic Modulation by Lactylation in Sepsis: Linking Metabolism to Immune Dysfunction.Journal of inflammation research · 2025Review
- Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals.JMIR human factors · 2024Article
- Clinical Informatics in Critical Care Medicine.The Yale journal of biology and medicine · 2023Review
- Real-Time Prediction of Sepsis in Critical Trauma Patients: Machine Learning-Based Modeling Study.JMIR formative research · 2023Article
- Desired Characteristics of a Clinical Decision Support System for Early Sepsis Recognition: Interview Study Among Hospital-Based Clinicians.JMIR human factors · 2022Article
- Impact of an electronic alert system for pediatric sepsis screening a tertiary hospital experience.Scientific reports · 2022Article
- Effectiveness of automated alerting system compared to usual care for the management of sepsis.NPJ digital medicine · 2022Article
- Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Pediatric, Neonatal, and Maternal Inpatients: Scoping Review.JMIR medical informatics · 2022Article
- Predicting Sepsis Mortality in a Population-Based National Database: Machine Learning Approach.Journal of medical Internet research · 2022Article
- Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Adult Inpatients: Scoping Review.Journal of medical Internet research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis and management of sepsis remain a global health care challenge. Digital technologies have the potential to improve sepsis care.
objectiveThe aim of this paper was to systematically review the evidence on the impact of digital alerting systems on sepsis related outcomes.
methodsThe following databases were searched for studies published from April 1964 to February 12, 2019, with no language restriction: EMBASE, MEDLINE, HMIC, PsycINFO, and Cochrane. All full-text reports of studies identified as potentially eligible after title and abstract reviews were obtained for further review. The search was limited to adult inpatients. Relevant articles were hand searched for other studies. Only studies with clear pre- and postalerting phases were included. Primary outcomes were hospital length of stay (LOS) and intensive care LOS, whereas secondary outcomes were time to antibiotics and mortality. Studies based solely on intensive care, case reports, narrative reviews, editorials, and commentaries were excluded. All other trial designs were included. A qualitative assessment and meta-analysis were performed.
resultsThis review identified 72 full-text articles. From these, 16 studies met the inclusion criteria and were included in the final analysis. Of these, 8 studies reviewed hospital LOS, 12 reviewed mortality outcomes, 5 studies explored time to antibiotics, and 5 studies investigated intensive care unit (ICU) LOS. Both quantitative and qualitative assessments of the studies were performed. There was evidence of a significant benefit of digital alerting in hospital LOS, which reduced by 1.31 days (P=.014), and ICU LOS, which reduced by 0.766 days (P=.007). There was no significant association between digital alerts and mortality (mean decrease 11.4%; P=.77) or time to antibiotics (mean decrease 126 min; P=.13).
conclusionsThis review highlights that digital alerts can considerably reduce hospital and ICU stay for patients with sepsis. Further studies including randomized controlled trials are necessary to confirm these findings and identify the choice of alerting system according to the patient status and pathological cohort.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.