Evidence map›Paper›PMID 31859506›Full record

ArticleJournal of the American Chemical Society2020

Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency.

Joseph K Vasquez, Korbin H J West, Tian Yang, Thomas J Polaske, Gabriel Cornilescu, Marco Tonelli, Helen E Blackwell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Synthetic Peptides Capable of Potent MultigroupJournal of the American Chemical Society · 2024
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Joseph K VasquezDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Korbin H J WestDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0002-4209-3650
Tian YangDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Thomas J PolaskeDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Gabriel CornilescuNational Magnetic Resonance Facility at Madison , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0002-1204-8904
Marco TonelliNational Magnetic Resonance Facility at Madison , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Helen E BlackwellDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0003-4261-8194
University of Wisconsin–Madison · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2012 to 2019
$9.4M
900 MHz NMR Spectrometer Biomolecular InvestigationsP41GM066326 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN L · 2002 to 2006
$5.0M
WIDE-BORE 9.4 TESLA NMR SPECTROMETER FOR UW-MADISONS10RR002781 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1986 to 1986
–
CONSOLE UPGRADES FOR NMR FACILITYS10RR008438 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1993 to 1993
–
NCRR NIH HHS S10 RR002781NCRR NIH HHS S10 RR008438NIGMS NIH HHS P41 GM066326NIGMS NIH HHS P41 GM103399NIGMS NIH HHS T32 GM008349NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

We report the solution-phase structures of native signal peptides and related analogs capable of either strongly agonizing or antagonizing the AgrC quorum sensing (QS) receptor in the emerging pathogen

Indexed as

Quorum SensingProtein Sorting SignalsStaphylococcus epidermidisProtein Sorting Signals

Identifiers

PMID31859506
PMCPMC6962532
OpenAlexW2996080918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.