Evidence map›Paper›PMID 31859455›Full record

ArticlePersonality and mental health2020

General personality dimensions, impairment and treatment response in obsessive-compulsive disorder.

Jack Samuels, O Joseph Bienvenu, Janice Krasnow, Ying Wang, Marco A Grados, Bernadette Cullen, Fernando S Goes, Brion Maher, Benjamin D Greenberg, Nicole C Mclaughlin and 11 more

Open access · greenAbstract read
In one paragraph

Article in Personality and mental health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 3 countries.

Jack SamuelsDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-6715-7905
O Joseph BienvenuDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Janice KrasnowDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ying WangDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Marco A GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Bernadette CullenDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Brion MaherDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Benjamin D GreenbergDepartment of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, Providence, Rhode Island, USA.
Nicole C MclaughlinDepartment of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, Providence, Rhode Island, USA.
Steven A RasmussenDepartment of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, Providence, Rhode Island, USA.
Abby J FyerDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, Columbia University, New York City, New York.
James A KnowlesDepartment of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York.
James T MccrackenDepartment of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles, Los Angeles, California.
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles, Los Angeles, California.
Dan GellerDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.
S Evelyn StewartDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver.
Dennis L MurphyLaboratory of Clinical Science, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland, USA.
Yin-Yao ShugartUnit of Statistical Genomics, Division of Intramural Research, National Institute of Mental Health, Bethesda, MD, USA.
Mark A RiddleDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gerald NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USProvidence College · USNational Institute of Mental Health · USUniversity of California, Los Angeles · USHarvard University · USNew York Psychoanalytic Society and Institute · USSUNY Downstate Health Sciences University · USUniversity of British Columbia · CA

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDERR01MH050214 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 1995 to 2005
$6.6M
OCD Collaborative Genetics Association StudyR01MH071507 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 2007 to 2010
$6.5M
TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Obsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079489 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI GELLER, DANIEL A · 2007 to 2010
$3.4M
OCD Collaborative Genetics Association StudyR01MH079488 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FYER, ABBY J · 2007 to 2010
$906k
Obsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079494 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KNOWLES, JAMES A · 2007 to 2011
$840k
Personality, anxiety, and depression in community adultsK23MH064543 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BIENVENU, O. JOSEPH · 2003 to 2007
$839k
OCD Collaborative Genetics Association StudyR01MH079487 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2007 to 2010
$797k
NCRR NIH HHS M01 RR000052NIH HHS K23-MH-64543NIH HHS MH071507NIH HHS MH079488NIH HHS MH079489NIH HHS MH079494NIH HHS MH50214NIH HHS MH79487NIH HHS NIH/NCRR/OPD-GCRC RR00052NIMH NIH HHS K23 MH064543NIMH NIH HHS R01 MH050214NIMH NIH HHS R01 MH071507NIMH NIH HHS R01 MH079487NIMH NIH HHS R01 MH079488NIMH NIH HHS R01 MH079489NIMH NIH HHS R01 MH079494NIMH NIH HHS T32 MH073517
6 · The paper itself

Abstract

General personality dimensions are associated with clinical severity and treatment response in individuals with depression and many anxiety disorders, but little is known about these relationships in individuals with obsessive-compulsive disorder (OCD). Individuals in the current study included 705 adults with OCD who had participated in family and genetic studies of the disorder. Participants self-completed the Neuroticism, Extraversion, Openness Personality Inventory or Neuroticism, Extraversion, Openness Five-Factor Inventory-3. Relationships between personality scores, and subjective impairment and OCD treatment response, were evaluated. The odds of subjective impairment increased with (unit increase in) the neuroticism score (odds ratio, OR = 1.03; 95% CI = 1.01-1.04; p < 0.01) and decreased with extraversion scores (OR = 0.98; 95% CI = 0.96-0.99; p < 0.01). The odds of reporting a good response to serotonin/selective serotonin reuptake inhibitors (OR = 1.02; 95% CI = 1.01-1.04; p < 0.01) or cognitive behavioural therapy (OR = 1.03; 95% CI = 1.01-1.05; p < 0.01) increased with the extraversion score. The magnitude of these relationships did not change appreciably after adjusting for other clinical features related to one or more of the personality dimensions. The findings suggest that neuroticism and extraversion are associated with subjective impairment, and that extraversion is associated with self-reported treatment response, in individuals with OCD. © 2019 John Wiley & Sons, Ltd.

Indexed as

Extraversion, PsychologicalNeuroticismSeverity of Illness IndexAdolescentAdultAgedCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderSerotonin AgentsTreatment OutcomeYoung AdultSerotonin Agents

Identifiers

PMID31859455
PMCPMC7202992
OpenAlexW2996506217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.