Evidence map›Paper›PMID 31859406›Full record

ArticleChembiochem : a European journal of chemical biology2020

A Structural Rationale for N-Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand-Gated Ion Channels.

Mathew J Jones, Alice Dawson, Tim G Hales, William N Hunter

Open access · bronzeAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mathew J JonesDivision of Biological Chemistry and Drug Discovery School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK.ORCID 0000-0002-8951-2939
Alice DawsonDivision of Biological Chemistry and Drug Discovery School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK.ORCID 0000-0002-3284-553X
Tim G HalesDivision of Systems Medicine, School of Medicine, Ninewells Hospital, University of Dundee, Dundee, DD1 9SY, UK.ORCID 0000-0002-2040-9714
William N HunterDivision of Biological Chemistry and Drug Discovery School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK.ORCID 0000-0002-6019-3102
University of Dundee · GB

Funding

Wellcome Trust 094090Wellcome Trust 203751
6 · The paper itself

Abstract

Bicuculline, a valued chemical tool in neurosciences research, is a competitive antagonist of specific GABA

Indexed as

Ion Channel GatingAmino Acid SequenceBicucullineBinding SitesGABA AntagonistsHumansModels, MolecularProtein ConformationReceptors, GABA-AReceptors, GlycineSequence HomologyBicucullinebicuculline methochlorideGABA AntagonistsReceptors, GABA-AReceptors, Glycineacetylcholine-binding proteinsalkaloidscompetitive antagonistscrystal structuresGABAA receptorsglycine receptor

Identifiers

PMID31859406
PMCPMC7611415
OpenAlexW2996585253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.