ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Stratifying risk for dementia onset using large-scale electronic health record data: A retrospective cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Risk factors and risk stratification approaches for delirium screening: A Geriatric Emergency Department Guidelines 2.0 systematic review.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2024Pooled it
- Natural language processing with machine learning methods to analyze unstructured patient-reported outcomes derived from electronic health records: A systematic review.Artificial intelligence in medicine · 2023Pooled it
- Natural language processing in clinical neuroscience and psychiatry: A review.Frontiers in psychiatry · 2022Pooled it
- Alignment of natural language processing-derived RDoC scores with depression, anhedonia, and anxiety in psychiatric electronic health records.NPP - digital psychiatry and neuroscience · 2026Article
- Predicting hospice eligibility among dementia patients using language models.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Integrative Multi-Omics and Routine Blood Analysis Using Deep Learning: Cost-Effective Early Prediction of Chronic Disease Risks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Reasoning language models for more transparent prediction of suicide risk.BMJ mental health · 2025Article
- Dual-stream algorithms for dementia detection: Harnessing structured and unstructured electronic health record data, a novel approach to prevalence estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Detection Bias in EHR-Based Research on Clinical Exposures and Dementia.JAMA network open · 2025Article
- Natural language processing of electronic health records for early detection of cognitive decline: a systematic review.NPJ digital medicine · 2025Article
- Article
- The relationship between dementia staging scales, cognitive-behavioral scales and functionality in patients with cognitive impairment.PloS one · 2025Article
- Disease-Specific Risk Models for Predicting Dementia: An Umbrella Review.Life (Basel, Switzerland) · 2024Review
- Extracting Critical Information from Unstructured Clinicians' Notes Data to Identify Dementia Severity Using a Rule-Based Approach: Feasibility Study.JMIR aging · 2024Article
- Digital Neuropsychology beyond Computerized Cognitive Assessment: Applications of Novel Digital Technologies.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Review
- Dementia and electronic health record phenotypes: a scoping review of available phenotypes and opportunities for future research.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Extraction of clinical phenotypes for Alzheimer's disease dementia from clinical notes using natural language processing.JAMIA open · 2023Article
- Recommended practices and ethical considerations for natural language processing-assisted observational research: A scoping review.Clinical and translational science · 2023Article
- Can Patients with Dementia Be Identified in Primary Care Electronic Medical Records Using Natural Language Processing?Journal of healthcare informatics research · 2023Article
- Characteristics of Dimensional Psychopathology in Suicidal Patients With Major Psychiatric Disorders and Its Association With the Length of Hospital Stay: Algorithm Validation Study.JMIR mental health · 2021Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
introductionPreventing dementia, or modifying disease course, requires identification of presymptomatic or minimally symptomatic high-risk individuals.
methodsWe used longitudinal electronic health records from two large academic medical centers and applied a validated natural language processing tool to estimate cognitive symptomatology. We used survival analysis to examine the association of cognitive symptoms with incident dementia diagnosis during up to 8 years of follow-up.
resultsAmong 267,855 hospitalized patients with 1,251,858 patient years of follow-up data, 6516 (2.4%) received a new diagnosis of dementia. In competing risk regression, an increasing cognitive symptom score was associated with earlier dementia diagnosis (HR 1.63; 1.54-1.72). Similar results were observed in the second hospital system and in subgroup analysis of younger and older patients. DISCUSSION: A cognitive symptom measure identified in discharge notes facilitated stratification of risk for dementia up to 8 years before diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.