Evidence map›Paper›PMID 31859127›Full record

ArticleJournal of clinical lipidology

Postprandial remodeling of high-density lipoprotein following high saturated fat and high carbohydrate meals.

Michelle Averill, Katya B Rubinow, Kevin Cain, Jake Wimberger, Ilona Babenko, Jessica O Becker, Karen E Foster-Schubert, David E Cummings, Andrew N Hoofnagle, Tomas Vaisar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  4. Review
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  8. Article
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  12. HDL Composition, Heart Failure, and Its Comorbidities.Frontiers in cardiovascular medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michelle AverillNutritional Sciences Department, University of Washington, Seattle, WA, USA.
Katya B RubinowDivision of Metabolism, Endocrinology, and Nutrition, UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Kevin CainDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Jake WimbergerDivision of Metabolism, Endocrinology, and Nutrition, UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Ilona BabenkoDivision of Metabolism, Endocrinology, and Nutrition, UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Jessica O BeckerDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Karen E Foster-SchubertDepartment of Medicine, University of Washington, Seattle, WA, USA.
David E CummingsDepartment of Medicine, University of Washington, Seattle, WA, USA.
Andrew N HoofnagleDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Tomas VaisarDivision of Metabolism, Endocrinology, and Nutrition, UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA. Electronic address: tvaisar@uw.edu.

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Meal Initiation and Energy Homeostasis: Role of GhrelinR01DK061516 · NIDDK · UNIVERSITY OF WASHINGTON · PI CUMMINGS, DAVID EUSTACE · 2002 to 2009
$1.6M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK061516
6 · The paper itself

Abstract

backgroundHumans spend most of the time in the postprandial state, yet most knowledge about high-density lipoproteins (HDL) derives from the fasted state. HDL protein and lipid cargo mediate HDL's antiatherogenic effects, but whether these HDL constituents change in the postprandial state and are affected by dietary macronutrients remains unknown.

objectivesThis study aimed to assess changes in HDL protein and lipid composition after the consumption of a high-carbohydrate or high saturated fat (HSF) meal.

methodsWe isolated HDL from plasma collected during a randomized, cross-over study of metabolically healthy subjects. Subjects consumed isocaloric meals consisting predominantly of either carbohydrate or fat. At baseline and at 3 and 6 hours postprandial, we quantified HDL protein and lipid composition by liquid chromatography-mass spectrometry.

resultsA total of 15 subjects were included (60% female, aged 34 ± 15 years, body mass index: 24.1 ± 2.7 kg/m

conclusionMeal macronutrient content acutely affects HDL composition in the postprandial state, with the HSF meal resulting in enrichment of HDL phospholipid content with possible consequences for HDL function.

Indexed as

AdultBlood GlucoseBody Mass IndexCarbohydratesCholesterol, LDLDietary FatsEatingFastingFatty AcidsFemaleHumansLipidomicsLipoproteins, HDLMaleMealsObesityBlood GlucoseCarbohydratesCholesterol, LDLDietary FatsFatty AcidsLipoproteins, HDLTriglyceridesDietHigh-density lipoproteinHigh-density lipoprotein/metabolismHigh-density lipoprotein remodelingLipidomic analysisLipoproteinsProteomic analysis

Identifiers

PMID31859127
PMCPMC7085425

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.