ArticleNeuron2020
Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.
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In one paragraph
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- The Efficacy and Safety of Transcranial Direct Current Stimulation for Cerebellar Ataxia: a Systematic Review and Meta-Analysis.Cerebellum (London, England) · 2021Pooled it
- Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6.Annals of neurology · 2026Article
- Cerebellar Purkinje cell firing reduction contributes to aging-related declining motor coordination in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases.Journal of Huntington's disease · 2025Review
- Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1).Life (Basel, Switzerland) · 2025Article
- Insights into RNA-mediated pathology in new mouse models of Huntington's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients.Science translational medicine · 2024Article
- Cohort-specific boolean models highlight different regulatory modules during Parkinson's disease progression.iScience · 2024Article
- Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway-mediated neuroinflammation in db/db mice.Journal of molecular medicine (Berlin, Germany) · 2024Article
- Toll-like receptor 4 deficiency in Purkinje neurons drives cerebellar ataxia by impairing the BK channel-mediated after-hyperpolarization and cytosolic calcium homeostasis.Cell death & disease · 2024Article
- Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue.Cell reports methods · 2024Article
- Review
- Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits.Scientific reports · 2024Article
- Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1.Neuron · 2024Article
- Widespread alternative splicing dysregulation occurs presymptomatically in CAG expansion spinocerebellar ataxias.Brain : a journal of neurology · 2024Article
- Functional implications of paralog genes in polyglutamine spinocerebellar ataxias.Human genetics · 2023Review
- Physiological Recordings of the Cerebellum in Movement Disorders.Cerebellum (London, England) · 2023Review
- Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1.Neuron · 2023Article
- Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia.Life (Basel, Switzerland) · 2023Review
- Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 4 countries.
Colleen A StoyasDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
David D BushartDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
Pawel M SwitonskiDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Molecular Biomedicine, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14 Str., 61-704 Poznan, Poland.
Jacqueline M WardDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Akshay AlaghattaDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Mi-Bo TangDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000 Henan, China.
Chenchen NiuDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Mandheer WadhwaDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Haoran HuangDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
Alex SavchenkoDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Karim GarianiLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Fang XieDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Joseph R DelaneyDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Terry GaasterlandInstitute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Johan AuwerxLaboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Vikram G ShakkottaiDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: vikramsh@med.umich.edu.
Albert R La SpadaDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: al.laspada@duke.edu.
Duke University · USUniversity of California, San Diego · USUniversity of Michigan–Ann Arbor · USÉcole Polytechnique Fédérale de Lausanne · CHFirst Affiliated Hospital of Zhengzhou University · CN
Funding
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3MMichigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERTS, SCOTT · 2016 to 2020
$10.1MSCA7 RETINAL DEGENERATION: MOLECULAR BASIS &THERAPYR01EY014061 · NEI · UNIVERSITY OF WASHINGTON · PI ALBERT R LA SPADA · 2002 to 2026
$8.4MIdentifying symptomatic and neuroprotective strategies for cerebellar ataxiaR01NS085054 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI SHAKKOTTAI, VIKRAM GOVINDARAJU · 2013 to 2023
$4.3MMolecular genetic regulation of autophagy in health and neurodegenerative diseaseR01AG033082 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LA SPADA, ALBERT R · 2009 to 2019
$4.0MTranslational Systems Genetics of Mitochondria, Metabolism, and AgingR01AG043930 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2013 to 2017
$2.5MCopy Number Alterations in Low Mutation CancerR00CA207729 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DELANEY, JOE R · 2019 to 2021
$730kCopy Number Alterations in Low Mutation CancerK99CA207729 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DELANEY, JOE R · 2017 to 2018
$230kNCI NIH HHS K99 CA207729NCI NIH HHS R00 CA207729NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY014061NIA NIH HHS P30 AG053760NIA NIH HHS R01 AG033082NIA NIH HHS R01 AG043930NINDS NIH HHS R01 NS085054
Abstract
Sirtuin 1 (Sirt1) is a NAD
Indexed as
AnimalsCalciumCell LineCerebellumFemaleHomeostasisHumansMaleMiceMice, Inbred C57BLMice, TransgenicNeuroprotectionNiacinamideOrgan Culture TechniquesSignal TransductionSirtuin 1CalciumNiacinamideSirt1 protein, mouseSirtuin 1calciumcerebellumNADneurodegenerationneuronal excitabilityneuroprotectionpotassium channelPurkinje neuronsirtuinspinocerebellar ataxia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.